TRP Channels in Drug Discovery

Volume I

Häftad, Engelska, 2016

AvArpad Szallasi,Tamás Bíró,Tamas Biro,Tamás

3 269 kr

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Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options.

Produktinformation

Utgivningsdatum2016-08-23
Mått178 x 254 x undefined mm
FormatHäftad
SpråkEngelska
SerieMethods in Pharmacology and Toxicology
Antal sidor446
FörlagHumana Press Inc.
ISBN9781493962815

Tillhör följande kategorier

Biokemi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Introduction to TRPs: A Quest for Novel Drug Targets.- TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development.- TRPA1 in Drug Discovery.- Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases.- TRPM2 Function and Potential as a Drug Target.- The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5.- The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis.- TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation.- TRPML Channels in Function, Disease, and Prospective Therapies.- The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1.- TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities.- Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”.- TRPV4 and Drug Discovery.- TRP Expression and Function in the Lung Airways.- Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells.- Endotoxin-Induced Airway Inflammation and Asthma Models.- Enhanced Cough, Animal Models.- Capsaicin Inhalation Test in Man.- TRP Channels in the Genitourinary (GU) Tract.- Animal Models of Cystitis.- Overactive Bladder Models.

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