• Definitions and scope of treatment-refractory schizophrenia.- Biology of schizophrenia: Is treatment-refractoriness synonymous with severity of illness.- Evolution of refractoriness.- Medical and psychiatric comorbidities: Complicating treatment expectations.- Overview of pharmacologic treatments and guidelines.- Clozapine: Gold standard treatment for refractory schizophrenia: Now or never.- Augmenting clozapine and other antipsychotic medications: Pharmacologic choices and differential outcomes.- Augmenting clozapine therapy: Emerging neuromodulatory strategies.- Cognitive remediation for refractory schizophrenia.- Psychological and familial therapies for refractory schizophrenia.- Vocational performance of patients with chronic schizophrenia.- Refractory schizophrenia and the criminal justice system: A failure of continuity of care and a real challenge.- Personalized medicine: A ‘game changer’ in the care of patients with treatment-refractory schizophrenia?

"This book is an excellent collection of chapters that collectively comprise the clinical and scientific knowledge base about refractory schizophrenia. ... For psychiatric practitioners, both prescribers and therapists, who manage schizophrenia on a daily basis, this book is a must own reference because of the wealth of helpful information between the covers." (Henry A. Nasrallah, Journal of Clinical Psychiatry, Vol. 76 (9), September, 2015) "This interesting book reviews treatment strategies and management options for those suffering from treatment-refractory schizophrenia (TRS). ... The target audience includes psychiatrists and other mental health professionals. Any clinicians who treat severely ill patients with psychiatric disorders would benefit from reading this book. ... This is an exceptional book covering a current critical issue for psychiatry and the patients suffering from unremitting psychosis. I highly recommend it." (Michael Joel Schrift, Doody's Book Reviews, July, 2014)