Treatment and Prevention of Malaria

• Antimalarial drugs and the control and elimination of malaria.- 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues.- Cinchona alkaloids: quinine and quinidine.- 8-Aminoquinolines: primaquine and tafenoquine.- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine.- Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone.- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions.- Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin.- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate.- Second generation peroxides: the OZs and artemisone.- Combination therapy in light of emerging artemisinin resistance.- New medicines to combat malaria: an overview of the global pipeline of therapeutics.- Molecular markers of Plasmodium resistance to antimalarials.- Prevention of malaria.- Malaria diagnostics: lighting the path.

From the reviews: "Staines and Krishna successfully captures the essence of what we know about antimalarials at the beginning of the second decade of the 21st century. ... the book is a welcome and highly valuable documentation on where we stand and offers valuable food for thought in the search for the way forward." (Martin P. Grobusch, Trends in Parasitology, September, 2012)