Dr. Mark J. Ashley is founder and president/CEO of Centre for Neuro Skills (CNS), which has operated postacute brain injury rehabilitation programs in Bakersfield, Los Angeles, Dallas, Fort Worth, and San Francisco since 1980. In 2011, Dr. Ashley participated in the Blue Ribbon Panel on Traumatic Brain Injury and Post-Traumatic Stress convened by Generals Peter W. Chiarelli and Joseph Dunford, and he established the CNS Clinical Research and Education Foundation, a nonprofit research organization. He serves on the board of directors of the Brain Injury Association of America (BIAA) and holds several positions in that organization, including chairman emeritus, chair of the fund development committee, and member of the Business and Professional Council. Dr. Ashley also serves on the board of directors of the California Brain Injury Association and is chairman emeritus. He is an adjunct professor at the Rehabilitation Institute of the College of Education at Southern Illinois University and a member of the advisory board of the Center for Applied Neuroscience, University of Cyprus. Dr. Ashley received his master’s degree in speech pathology and a doctorate of science from Southern Illinois University in Carbondale, Illinois. He is a licensed speech-language pathologist in California and Texas and is a certified case manager.Dr. David A. Hovda is the director of the UCLA Brain Injury Research Center, which was created in 1990. It incorporates teaching, research, patient care, and service for patients suffering from traumatic brain injury. Dr. Hovda has received a number of awards for his research on brain injury and recovery of function, including the "Strength of the Nation Award" from the United States Army in 2011. This is the highest civilian award given by the Secretary of the Army in recognition of Dr. Hovda’s efforts to help treat military personnel suffering from mild traumatic brain injury returning from theater. In addition, Dr. Hovda received the Alumni Association’s James F. Zimmerman Award from the University of New Mexico in 2012 for his research accomplishments recognized in the field of traumatic brain injury. Dr. Hovda is most well known internationally for his translational work on the pathobiology of traumatic brain injury and has devoted most of his career to understanding the mechanisms of recovery of function. Dr. Hovda continues to serve as a consultant for professional sport organizations as well as the Department of Defense, addressing issues related to traumatic brain injury and recovery of function. Dr. Hovda is a professor of neurosurgery and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA. He received his doctoral degree under the supervision of Dr. Dennis M. Feeney in the field of Physiological Psychology at the University of New Mexico. He completed his postdoctoral training in neurophysiology under Dr. Jamie Villablanca at UCLA.

• 4th EDITION TABLE OF CONTENTSNEUROSCIENCE Bioscience Indications for Chronic Disease Management and Neuromedical Interventions Following Traumatic Brain Injury– Mark J. Ashley, Grace S. Griesbach, David L. Ripley, Matthew J. Ashley The Neurobiology of Traumatic Brain Injury– Thomas C. Glen, Richard L. Sutton and David A. Hovda Repeat Traumatic Brain Injury Models – Mayumi Prins Neuroplasticity and Rehabilitation Therapy – Robert P. Lehr Environment Enrichment: A Preclinical Model of Neurorehabilitation for Traumatic Brain Injury – Corina O. Bondi & Anthony E. Kline Neuroanatomy of Basic Cognitive Function – Mark J. Ashley, Jessica G. Ashley & Matthew J. Ashley TBI Rehabilitation: Lessons Learned from Animal Studies about Mechanisms, Timing and Combinatorial Approaches– Dorothy A. Kozlowski Diet and Exercise Interventions to Promote Metabolic Homeostasis in TBI Pathology– Fernando Gomez-Pinilla Disruptions in Physical Substrates of Vision Following Traumatic Brain Injury– Richard E. Helvie Potential Utility of Resting State fMRI-Determined Functional Connectivity to Guide Neurorehabilitation – Neil G. Harris and Jessica G. Ashley TBI and Sensory Sensitivity: Translational Opportunities – Timothy W. Ellis and Jonathan Lifshitz The Neuroimaging Challenges in Hemispherectomy Patients– Zachary Jacokes, Avnish Bhattrai, Carinna Torgerson, Andrew Zywiec, Sumiko Abe, Andrei Irimia, Meng Law, Saman Hazany, and John Darrell Van Horn MEDICAL Clinical Management of the Minimally Conscious State– Yelena G. Bodien, Sabrina R. Taylor, and Joseph T. Giacino Neuropharmacologic Considerations in the Treatment of Vegetative State and Minimally Conscious State Following Brain Injury – Deborah L. Doherty Clinical Management of Pituitary Dysfunction After Traumatic Brain Injury – Adam H. Maghrabi, Brent E. Masel, Randall J. Urban, and David L. Ripley Neurotransmitters and Pharmacology– Ronald A. Browning and Richard W. Clough Pituitary Dysfunction After Traumatic Brain Injury – Tiffany Greco Increasing Physiologic Readiness to Improve Functional Independence Following Neurotrauma –Gregory J. O’Shanick and Ryan McQueen Assessment and Management of Mild Traumatic Brain Injury– Mark J. Ashley, Matthew J. Ashley Chronic Traumatic Encephalopathy (CTE) – Anne C. McKee Posttraumatic Epilepsy and Neurorehabilitation – Theresa D. Hernández, Sudha S. Tallavajhula, Kristina Legget, and Paul M. Levisohn THERAPY Evaluation of Traumatic Brain Injury Following Acute Rehabilitation– Mark J. Ashley Neuropsychology following Brain Injury: A Pragmatic Approach to Outcomes, Treatment, and Applications- James J. Mahoney, III Neuropsychological Interventions Following Traumatic Brain Injury– Jason W. Krellman, TheodoreTsaousides, and Wayne A. Gordon The Use of Applied Behavioral Analysis in Traumatic Brain Injury Rehabilitation – Craig S. Persel and Chris H. Persel Rehabilitation and Management of Visual Dysfunction Following Traumatic Brain Injury– Penelope S. Suter Remediative Approaches for Cognitive Disorders After TBI – Mark J. Ashley, Rose Leal, Zenobia Mehta, Jessica G. Ashley, Matthew J. Ashley Principles of Cognitive Rehabilitation in TBI: An Integrative Neuroscience Approach – Fofi Constantinidou and Robin D. Thomas Management of Residual Physical Deficits– Velda L. Bryan, David W. Harrington, Michael G. Elliott Undertaking Vocational Rehabilitation in TBI Rehabilitation – Mark J. Ashley, Joe Ninomiya, Jr., Amy Berryman, Karen Rasavage CASE MANAGEMENT The Contribution of Neuropsychological Evaluation to Traumatic Brain Injury Rehabilitation– Jay M. Uomoto Neurobehavioral Consequences of Mild Traumatic Brain Injury in Military Service Members and Veterans – Jay M. Uomoto, Sarah M. Wilson, Rhonda M. Williams, and Leigh A. Randa Issues in Aging Following Traumatic Brain Injury– Grace S. Griesbach, Mark J. Ashley, Alan Weintraub Children and Adolescents: Practical Strategies for School Participation and Transition – Roberta DePompei and Janet Siantz Tyler Long-Term Discharge Planning in Traumatic Brain Injury Rehabilitation – Mark J. Ashley and Susan M. Ashley Patients’ Rights and Responsibilities, Health Care Reform and Telehealth: Ethical Considerations – Thomas R. Kerkhoff and Stephanie L. Hanson

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Dr. Mark J. Ashley is founder and president/CEO of Centre for Neuro Skills (CNS), which has operated postacute brain injury rehabilitation programs in Bakersfield, Los Angeles, Dallas, Fort Worth, and San Francisco since 1980. In 2011, Dr. Ashley participated in the Blue Ribbon Panel on Traumatic Brain Injury and Post-Traumatic Stress convened by Generals Peter W. Chiarelli and Joseph Dunford, and he established the CNS Clinical Research and Education Foundation, a nonprofit research organization. He serves on the board of directors of the Brain Injury Association of America (BIAA) and holds several positions in that organization, including chairman emeritus, chair of the fund development committee, and member of the Business and Professional Council. Dr. Ashley also serves on the board of directors of the California Brain Injury Association and is chairman emeritus. He is an adjunct professor at the Rehabilitation Institute of the College of Education at Southern Illinois University and a member of the advisory board of the Center for Applied Neuroscience, University of Cyprus. Dr. Ashley received his master’s degree in speech pathology and a doctorate of science from Southern Illinois University in Carbondale, Illinois. He is a licensed speech-language pathologist in California and Texas and is a certified case manager.Dr. David A. Hovda is the director of the UCLA Brain Injury Research Center, which was created in 1990. It incorporates teaching, research, patient care, and service for patients suffering from traumatic brain injury. Dr. Hovda has received a number of awards for his research on brain injury and recovery of function, including the "Strength of the Nation Award" from the United States Army in 2011. This is the highest civilian award given by the Secretary of the Army in recognition of Dr. Hovda’s efforts to help treat military personnel suffering from mild traumatic brain injury returning from theater. In addition, Dr. Hovda received the Alumni Association’s James F. Zimmerman Award from the University of New Mexico in 2012 for his research accomplishments recognized in the field of traumatic brain injury. Dr. Hovda is most well known internationally for his translational work on the pathobiology of traumatic brain injury and has devoted most of his career to understanding the mechanisms of recovery of function. Dr. Hovda continues to serve as a consultant for professional sport organizations as well as the Department of Defense, addressing issues related to traumatic brain injury and recovery of function. Dr. Hovda is a professor of neurosurgery and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA. He received his doctoral degree under the supervision of Dr. Dennis M. Feeney in the field of Physiological Psychology at the University of New Mexico. He completed his postdoctoral training in neurophysiology under Dr. Jamie Villablanca at UCLA.

• 4th EDITION TABLE OF CONTENTSNEUROSCIENCE Bioscience Indications for Chronic Disease Management and Neuromedical Interventions Following Traumatic Brain Injury– Mark J. Ashley, Grace S. Griesbach, David L. Ripley, Matthew J. Ashley The Neurobiology of Traumatic Brain Injury– Thomas C. Glen, Richard L. Sutton and David A. Hovda Repeat Traumatic Brain Injury Models – Mayumi Prins Neuroplasticity and Rehabilitation Therapy – Robert P. Lehr Environment Enrichment: A Preclinical Model of Neurorehabilitation for Traumatic Brain Injury – Corina O. Bondi & Anthony E. Kline Neuroanatomy of Basic Cognitive Function – Mark J. Ashley, Jessica G. Ashley & Matthew J. Ashley TBI Rehabilitation: Lessons Learned from Animal Studies about Mechanisms, Timing and Combinatorial Approaches– Dorothy A. Kozlowski Diet and Exercise Interventions to Promote Metabolic Homeostasis in TBI Pathology– Fernando Gomez-Pinilla Disruptions in Physical Substrates of Vision Following Traumatic Brain Injury– Richard E. Helvie Potential Utility of Resting State fMRI-Determined Functional Connectivity to Guide Neurorehabilitation – Neil G. Harris and Jessica G. Ashley TBI and Sensory Sensitivity: Translational Opportunities – Timothy W. Ellis and Jonathan Lifshitz The Neuroimaging Challenges in Hemispherectomy Patients– Zachary Jacokes, Avnish Bhattrai, Carinna Torgerson, Andrew Zywiec, Sumiko Abe, Andrei Irimia, Meng Law, Saman Hazany, and John Darrell Van Horn MEDICAL Clinical Management of the Minimally Conscious State– Yelena G. Bodien, Sabrina R. Taylor, and Joseph T. Giacino Neuropharmacologic Considerations in the Treatment of Vegetative State and Minimally Conscious State Following Brain Injury – Deborah L. Doherty Clinical Management of Pituitary Dysfunction After Traumatic Brain Injury – Adam H. Maghrabi, Brent E. Masel, Randall J. Urban, and David L. Ripley Neurotransmitters and Pharmacology– Ronald A. Browning and Richard W. Clough Pituitary Dysfunction After Traumatic Brain Injury – Tiffany Greco Increasing Physiologic Readiness to Improve Functional Independence Following Neurotrauma –Gregory J. O’Shanick and Ryan McQueen Assessment and Management of Mild Traumatic Brain Injury– Mark J. Ashley, Matthew J. Ashley Chronic Traumatic Encephalopathy (CTE) – Anne C. McKee Posttraumatic Epilepsy and Neurorehabilitation – Theresa D. Hernández, Sudha S. Tallavajhula, Kristina Legget, and Paul M. Levisohn THERAPY Evaluation of Traumatic Brain Injury Following Acute Rehabilitation– Mark J. Ashley Neuropsychology following Brain Injury: A Pragmatic Approach to Outcomes, Treatment, and Applications- James J. Mahoney, III Neuropsychological Interventions Following Traumatic Brain Injury– Jason W. Krellman, TheodoreTsaousides, and Wayne A. Gordon The Use of Applied Behavioral Analysis in Traumatic Brain Injury Rehabilitation – Craig S. Persel and Chris H. Persel Rehabilitation and Management of Visual Dysfunction Following Traumatic Brain Injury– Penelope S. Suter Remediative Approaches for Cognitive Disorders After TBI – Mark J. Ashley, Rose Leal, Zenobia Mehta, Jessica G. Ashley, Matthew J. Ashley Principles of Cognitive Rehabilitation in TBI: An Integrative Neuroscience Approach – Fofi Constantinidou and Robin D. Thomas Management of Residual Physical Deficits– Velda L. Bryan, David W. Harrington, Michael G. Elliott Undertaking Vocational Rehabilitation in TBI Rehabilitation – Mark J. Ashley, Joe Ninomiya, Jr., Amy Berryman, Karen Rasavage CASE MANAGEMENT The Contribution of Neuropsychological Evaluation to Traumatic Brain Injury Rehabilitation– Jay M. Uomoto Neurobehavioral Consequences of Mild Traumatic Brain Injury in Military Service Members and Veterans – Jay M. Uomoto, Sarah M. Wilson, Rhonda M. Williams, and Leigh A. Randa Issues in Aging Following Traumatic Brain Injury– Grace S. Griesbach, Mark J. Ashley, Alan Weintraub Children and Adolescents: Practical Strategies for School Participation and Transition – Roberta DePompei and Janet Siantz Tyler Long-Term Discharge Planning in Traumatic Brain Injury Rehabilitation – Mark J. Ashley and Susan M. Ashley Patients’ Rights and Responsibilities, Health Care Reform and Telehealth: Ethical Considerations – Thomas R. Kerkhoff and Stephanie L. Hanson

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Dr. Mark J. Ashley is founder and president/CEO of Centre for Neuro Skills (CNS), which has operated postacute brain injury rehabilitation programs in Bakersfield, Los Angeles, Dallas, Fort Worth, and San Francisco since 1980. In 2011, Dr. Ashley participated in the Blue Ribbon Panel on Traumatic Brain Injury and Post-Traumatic Stress convened by Generals Peter W. Chiarelli and Joseph Dunford, and he established the CNS Clinical Research and Education Foundation, a nonprofit research organization. He serves on the board of directors of the Brain Injury Association of America (BIAA) and holds several positions in that organization, including chairman emeritus, chair of the fund development committee, and member of the Business and Professional Council. Dr. Ashley also serves on the board of directors of the California Brain Injury Association and is chairman emeritus. He is an adjunct professor at the Rehabilitation Institute of the College of Education at Southern Illinois University and a member of the advisory board of the Center for Applied Neuroscience, University of Cyprus. Dr. Ashley received his master’s degree in speech pathology and a doctorate of science from Southern Illinois University in Carbondale, Illinois. He is a licensed speech-language pathologist in California and Texas and is a certified case manager.Dr. David A. Hovda is the director of the UCLA Brain Injury Research Center, which was created in 1990. It incorporates teaching, research, patient care, and service for patients suffering from traumatic brain injury. Dr. Hovda has received a number of awards for his research on brain injury and recovery of function, including the "Strength of the Nation Award" from the United States Army in 2011. This is the highest civilian award given by the Secretary of the Army in recognition of Dr. Hovda’s efforts to help treat military personnel suffering from mild traumatic brain injury returning from theater. In addition, Dr. Hovda received the Alumni Association’s James F. Zimmerman Award from the University of New Mexico in 2012 for his research accomplishments recognized in the field of traumatic brain injury. Dr. Hovda is most well known internationally for his translational work on the pathobiology of traumatic brain injury and has devoted most of his career to understanding the mechanisms of recovery of function. Dr. Hovda continues to serve as a consultant for professional sport organizations as well as the Department of Defense, addressing issues related to traumatic brain injury and recovery of function. Dr. Hovda is a professor of neurosurgery and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA. He received his doctoral degree under the supervision of Dr. Dennis M. Feeney in the field of Physiological Psychology at the University of New Mexico. He completed his postdoctoral training in neurophysiology under Dr. Jamie Villablanca at UCLA.

• 4th EDITION TABLE OF CONTENTSNEUROSCIENCE Bioscience Indications for Chronic Disease Management and Neuromedical Interventions Following Traumatic Brain Injury– Mark J. Ashley, Grace S. Griesbach, David L. Ripley, Matthew J. Ashley The Neurobiology of Traumatic Brain Injury– Thomas C. Glen, Richard L. Sutton and David A. Hovda Repeat Traumatic Brain Injury Models – Mayumi Prins Neuroplasticity and Rehabilitation Therapy – Robert P. Lehr Environment Enrichment: A Preclinical Model of Neurorehabilitation for Traumatic Brain Injury – Corina O. Bondi & Anthony E. Kline Neuroanatomy of Basic Cognitive Function – Mark J. Ashley, Jessica G. Ashley & Matthew J. Ashley TBI Rehabilitation: Lessons Learned from Animal Studies about Mechanisms, Timing and Combinatorial Approaches– Dorothy A. Kozlowski Diet and Exercise Interventions to Promote Metabolic Homeostasis in TBI Pathology– Fernando Gomez-Pinilla Disruptions in Physical Substrates of Vision Following Traumatic Brain Injury– Richard E. Helvie Potential Utility of Resting State fMRI-Determined Functional Connectivity to Guide Neurorehabilitation – Neil G. Harris and Jessica G. Ashley TBI and Sensory Sensitivity: Translational Opportunities – Timothy W. Ellis and Jonathan Lifshitz The Neuroimaging Challenges in Hemispherectomy Patients– Zachary Jacokes, Avnish Bhattrai, Carinna Torgerson, Andrew Zywiec, Sumiko Abe, Andrei Irimia, Meng Law, Saman Hazany, and John Darrell Van Horn MEDICAL Clinical Management of the Minimally Conscious State– Yelena G. Bodien, Sabrina R. Taylor, and Joseph T. Giacino Neuropharmacologic Considerations in the Treatment of Vegetative State and Minimally Conscious State Following Brain Injury – Deborah L. Doherty Clinical Management of Pituitary Dysfunction After Traumatic Brain Injury – Adam H. Maghrabi, Brent E. Masel, Randall J. Urban, and David L. Ripley Neurotransmitters and Pharmacology– Ronald A. Browning and Richard W. Clough Pituitary Dysfunction After Traumatic Brain Injury – Tiffany Greco Increasing Physiologic Readiness to Improve Functional Independence Following Neurotrauma –Gregory J. O’Shanick and Ryan McQueen Assessment and Management of Mild Traumatic Brain Injury– Mark J. Ashley, Matthew J. Ashley Chronic Traumatic Encephalopathy (CTE) – Anne C. McKee Posttraumatic Epilepsy and Neurorehabilitation – Theresa D. Hernández, Sudha S. Tallavajhula, Kristina Legget, and Paul M. Levisohn THERAPY Evaluation of Traumatic Brain Injury Following Acute Rehabilitation– Mark J. Ashley Neuropsychology following Brain Injury: A Pragmatic Approach to Outcomes, Treatment, and Applications- James J. Mahoney, III Neuropsychological Interventions Following Traumatic Brain Injury– Jason W. Krellman, TheodoreTsaousides, and Wayne A. Gordon The Use of Applied Behavioral Analysis in Traumatic Brain Injury Rehabilitation – Craig S. Persel and Chris H. Persel Rehabilitation and Management of Visual Dysfunction Following Traumatic Brain Injury– Penelope S. Suter Remediative Approaches for Cognitive Disorders After TBI – Mark J. Ashley, Rose Leal, Zenobia Mehta, Jessica G. Ashley, Matthew J. Ashley Principles of Cognitive Rehabilitation in TBI: An Integrative Neuroscience Approach – Fofi Constantinidou and Robin D. Thomas Management of Residual Physical Deficits– Velda L. Bryan, David W. Harrington, Michael G. Elliott Undertaking Vocational Rehabilitation in TBI Rehabilitation – Mark J. Ashley, Joe Ninomiya, Jr., Amy Berryman, Karen Rasavage CASE MANAGEMENT The Contribution of Neuropsychological Evaluation to Traumatic Brain Injury Rehabilitation– Jay M. Uomoto Neurobehavioral Consequences of Mild Traumatic Brain Injury in Military Service Members and Veterans – Jay M. Uomoto, Sarah M. Wilson, Rhonda M. Williams, and Leigh A. Randa Issues in Aging Following Traumatic Brain Injury– Grace S. Griesbach, Mark J. Ashley, Alan Weintraub Children and Adolescents: Practical Strategies for School Participation and Transition – Roberta DePompei and Janet Siantz Tyler Long-Term Discharge Planning in Traumatic Brain Injury Rehabilitation – Mark J. Ashley and Susan M. Ashley Patients’ Rights and Responsibilities, Health Care Reform and Telehealth: Ethical Considerations – Thomas R. Kerkhoff and Stephanie L. Hanson

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