Trauma Induced Coagulopathy

Ernest E. Moore, MD is Editor, Journal of Trauma and Acute Care Surgery (LWW)

• Cell-Mediated Hemostasis.- Antithrombin Contributions to Physiological Hemostasis and Thrombosis Prevention, and its Dysregulation in Trauma and TIC.- Physiology of Hemostasis: Plasmin-antiplasmin system.- Thrombin Formation.- Fibrinogen.- Activated Protein C.- Pathogenesis of Trauma Induced Coagulopathy: The Endothelium.- Platelets.- Fibrinolysis.- Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy.- DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis.- The Complement System and Coagulation.- Disseminated Intravascular Coagulation.- Prothrombin and Partial Thromboplastin Time.- Fibrinogen Assays.- Platelet Aggregometry.- Thrombelastography.- Rotational Thromboelastometry (ROTEM®).- Red Blood Cell: Manufacture, Storage, and Transfusion.- Plasma Transfusion.- Cryoprecipitate Transfusion.- The Evolving Role of Platelets in Trauma Care.- Massive Transfusion Protocols.- Fibrinogen and Clotting Factor Replacement.- Anti-Fibrinolytics.- Venous Thromboembolism.- Congenital and Acquired Hypercoagulable States.- Coagulopathy in Traumatic Brain Injury (TBI).- Liver Disease.- Hemostatic Abnormalities in Renal Disease.- Pediatrics.- Pregnancy.- Management of Chronically Anticoagulated Patients.- Animal Models.-

“This is a collection of reviews describing the most important early complication of injury. … Senior trainees, basic scientists seeking clinical connection, and surgeons, particularly those in academic trauma practice, are an appropriate audience for this book from international authorities. … This is an important contribution that will guide senior clinicians and basic scientists seeking to better define this important clinical problem. The editors have been careful to assemble rigorous reviews that indicate the strengths and limitations of contemporary evidence.” (David J. Dries, Doody's Book Reviews, August, 2016)