Translational Research Methods in Neurodevelopmental Disorders

Inbunden, Engelska, 2022

Av Stéphane Martin, Frédéric Laumonnier, Stephane Martin, Frederic Laumonnier

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This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents.

Produktinformation

Utgivningsdatum2022-09-30
Mått178 x 254 x 21 mm
Vikt729 g
FormatInbunden
SpråkEngelska
SerieNeuromethods
Antal sidor264
FörlagSpringer-Verlag New York Inc.
ISBN9781071625682

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Using Lentiviral shRNA Delivery to Knock-Down Proteins in Cultured Neurons and In Vivo.- Synaptosomal Preparation and Its Application in Preclinical Studies.- Assessing the Nanoscale Organization of Excitatory and Inhibitory Synapses using Recombinant Probes to Visualize Endogenous Synaptic Proteins.- Agonist-Induced Functional Analysis and Cell Sorting (aiFACS) to Select and Characterize Interneurons during Brain Development.- A CRISPR/Cas9-Based Toolkit to Test Gain- and Loss-of-Gene Function in Brain Organoids.- Assessment of Adult Mouse Brain NeuroAnatomical Phenotypes using Quantitative and Precision Histology.- Leveraging Microelectrode Array Technology for Phenotyping Stem Cell-Derived Neurodevelopmental Disease Models.- Humanized Chimeric Mouse Models to Study Human Neural Development and Pathogenesis of Brain Diseases.- In Vivo Manipulations to Correct for Behavioral Phenotypes in Cognitive Disorder Mouse Models.- Assessing Dyadic Social Interactions in Rodent Models of Neurodevelopmental Disorders.- Central and Peripheral Explorations by Metabolomics to Study Neurodevelopmental Disorders.- Genetic Engineering of Non-Human Primates Models for Studying Neurodevelopmental Disorders.