Translational Pain Research

Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USAAlan Light, Research Professor of Anesthesiology, University of Utah, USA

• Painful Multi-Symptom Disorders: A Systems Perspective. Neurotrophic Factors and Nociceptor Sensitization. The Role of Visceral Afferents in Disease. Cancer Pain: From the Development of Mouse Models to Human Clinical Trials. Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States. Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes. Transgenic Mouse Models for the Tracing of "Pain" Pathways. Cytokines in Pain. Glial Modulation in Pain States: Translation into Humans. On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain. Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes. Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents. Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection? What Can Neuroimaging Tell Us about Central Pain? Human Brain Imaging Studies of Chronic Pain: Translational Opportunities. Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs. Large Animal Models for Pain Therapeutic Development. Drug Discovery and Development for Pain. Index.

As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference…In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding.--Journal of the American Association for Laboratory Animal Science, September 2010