Translational Neuroscience

James E. Barrett is Professor and Chair of Pharmacology and Physiology and Director of the Drug Discovery and Development Program at Drexel University College of Medicine, Philadelphia, PA, USA. Joseph T. Coyle is the Eben S. Draper Chair of Psychiatry and Neuroscience at McLean Hospital, Harvard Medical School, Belmont, MA, USA. Michael Williams is Vice President, Cephalon Inc, Frazer, PA, USA.

• Preface; 1. The initial discovery and development of drugs to treat psychiatric disorders: historical perspectives M. Williams and J. E. Barrett; 2. Translational approaches to the treatment of anxiety K. J. Ressler; 3. Translational approaches to the treatment of depression and bipolar disorder Husseini Manji; 4. Translational medicine and schizophrenia Don Goff; 5. Translational medicine and sleep disorders M. Williams; 6. Substance abuse: translational models and methods for treatment Charles P. O'Brien; 7. Section summary and perspectives: translational medicine in psychiatry J. Coyle; 8. Historical perspectives on the discovery and development of drugs to treat neurological disorders J. Coyle and M. Williams; 9. Alzheimer's disease: translational science in discovery and development Donald L. Price; 10. Translational medicine and pain therapeutics Tony Bannon; 11. Multiple sclerosis and translational medicine Alfred Sandrock; 12. Parkinson's disease: translational science and clinical development Jiang-Fan Chen; 13. Translational approaches to the drug development in amyotropic lateral sclerosis Nicholas J. Maragakis; 14. Epilepsy and the integration of translational medicine M. Gasior and Frank Wiegand; 15. Section summary and perspectives: translational medicine in neurology J. Coyle; 16. Historical perspectives on the use of therapeutic agents to treat neurodevelopmental disorders Chris McDougle and Kimberly Stigler; 17. Autistic spectrum disorders and fragile X: translational approaches Tim Roberts; 18. Translational approaches to attention deficit hyperactivity disorder Craig Berridge; 19. Section summary and perspectives: translational medicine in neurodevelopmental disorders J. Coyle and J. E. Barrett; 20. Epigenetic regulation and translational medicine Farah D. Lubin; 21. General conclusions: challenges, promises and future directions of translational medicine in the neurosciences D. L. Braff; Index.