This book constitutes the thoroughly refereed proceedings of the 17th International Conference on Design Science Research in Information Systems and Technology, DESRIST 2022, held in Tampa, FL, USA, in June 2022.The 37 revised full research papers, included in the volume were carefully reviewed and selected from 103 submissions. They are organized in the following topical sections: ​Transdisciplinary Research & DSR (theme Track); Blockchain Information Systems; Intelligent Systems and Human Interaction; Healthcare Systems and Quality of Life; Innovation and Entrepreneurship; Sustainability and Responsible Design (Environmental Issues, Human Values and ethical Design); Human Safety and Cybersecurity; Emerging DSR Methods and Processes; Designers and Collaborative DSR; and Education and DSR.