Davide Martino, MD PhD Associate Professor Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary; The Hotchkiss Brain Institute and The Mathison Centre for Mental Health Research and Education, Calgary, Canada; Alberta Children's Hospital Research Institute, Calgary, Canada James F Leckman, MD, PhD Neison Harris Professor of Child Psychiatry, Paediatrics, & PsychologyYale Child Study Center, Yale University, New Haven CT

• ForewordIntroductionContributors SECTION ONE: CLINICAL PHENOMENOLOGY AND EPIDEMIOLOGY Chapter 1 Phenomenology of tics and sensory urges: the self under siege James F. Leckman, Michael H. Bloch, Denis G. Sukhodolsky, Lawrence Scahill and Robert A. King Chapter 2 The phenomenology of attention deficit/hyperactivity disorder in Tourette syndrome Aribert Rothenberger and Veit Roessner Chapter 3 The phenomenology of obsessive-compulsive symptoms in Tourette syndrome Ygor A. Ferrao, Pedro G. de Alvarenga, Ana G. Hounie, Maria Alice de Mathis, Luis Carlos Farhat, Maria C do Rosario and Euripedes Miguel Chapter 4 Other psychiatric co-morbidities in Tourette syndrome Danielle C. Cath, Kirsten R. Müller-Vahl and Carol A. Mathews Chapter 5 Clinical course and adulthood-outcome in Tourette syndromeMichael H. Bloch Chapter 6 Health outcomes, health status and mortality in Tourette syndrome and chronic tic disorderLorena Fernandez de la Cruz and David Mataix-Cols Chapter 7 The prevalence, incidence and risk of Tourette syndromeLawrence Scahill, Erla Thorsteinsson and Soren Dalsgaard SECTION TWO: ETIOLOGY Chapter 8 Genetic susceptibility in Tourette syndrome Sarah B. Abdallah and Thomas V. Fernandez Chapter 9 Perinatal adversities and Tourette syndrome Pieter J. Hoekstra and Andrea Dietrich Chapter 10 Infections and tic disorders Davide Martino, Alex Medina Escobar, Osman Malik and Tammy Hedderly SECTION 3 PATHOPHYSIOLOGY Chapter 11 Cellular and molecular pathology in Tourette syndrome Liana Fasching, Melanie Brady and Flora M. Vaccarino Chapter 12 Abnormalities of neural microcircuits in Tourette syndrome Katherine Dyke, Valerie Brandt, Tobias Bäumer and Alexander Münchau Chapter 13 Neurobiology and functional anatomy of tic disorders Deanna J. Greene, Soyoung Kim, Kevin J. Black and Bradley L. Schlaggar Chapter 14 Tourette syndrome: circuits and neurotransmitters Harvey S. Singer and Farhan Augustine Chapter 15 Neuroimmunoendocrinology of Tourette syndrome Davide Martino, Isaac N.S. Johnson, Alex Medina Escobar and James F. Leckman Chapter 16 Animal models of tic disorders Marco Bortolato and Roberto Cadeddu Chapter 17 Inhibitory control and tic generationLille Kurvits and Christos Ganos SECTION 4 DIAGNOSIS AND ASSESSMENT Chapter 18 Pathways from genes to symptoms in Tourette syndromeValsamma Eapen, Iain Perkes and Roxanne Golf Chapter 19 The differential diagnosis of tic disorders Roger Kurlan Chapter 20 Comprehensive assessment strategies Robert A. King and Angeli Landeros-Weisenberger Chapter 21 Clinical rating instruments in Tourette syndrome Andrea E. Cavanna Chapter 22 Neuropsychological assessment in Tourette syndrome Tara Murphy, Virginie Czernecki, Zsanett Tarnok and Daniel Stark Chapter 23 Social and adaptive functioning in Tourette syndrome Denis G. Sukhodolsky, Carla Kalvin, Bekir B. Artukoglu, Virginia W. Eicher and James F. Leckman SECTION 5 TREATMENT Chapter 24 Psychoeducational interventions: what every parent and family member needs to know Eli R. Lebowitz and Bekir B. Artukoglu Chapter 25 Behavioral and cognitive-behavioral therapy for Tourette's disorder Joseph McGuire, Matthew R. Capriotti, Douglas W. Woods and John Piacentini Chapter 26 Pharmacological treatment of tics Veit Roessner and Aribert Rothenberger Chapter 27 Treatment of psychiatric comorbidities in Tourette syndrome Francesco Cardona and Renata Rizzo Chapter 28 Surgical treatment of Tourette syndrome Domenico Servello, Wissam Deeb, Tommaso F. Galbiati and Mauro Porta Chapter 29 Complementary and integrative health medicine in Tourette syndrome Maria Cruz and Barbara Coffey SECTION 6 RESOURCES & SUPPORT Chapter 30 Information and social support for patients and families Kirsten Müller-Vahl Chapter 31 Information and support for educators Sheryl K. Pruitt and Leslie E. Packer Chapter 32 Tourette syndrome support organisations around the world Seonaid Anderson, Annet Hejerman-Holtgrefe and Andreas Hartmann

This second edition is a comprehensive, thorough, and up-to-date review from international experts regarding the current understanding of Tourette syndrome. The book provides a reference for a wide audience but is particularly applicable to those treating these individuals who seek a better understanding of this complex, multifaceted disorder.