Tissue-Specific Estrogen Action

• Interfering with the Dynamics of Estrogen Receptor-Regulated Transcription.- Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues.- Genetic Dissection of Estrogen Receptor Signaling In Vivo.- Of Mice and Men: The Many Guises of Estrogens.- Estradiol Action in Atherosclerosis and Reendothelialization.- Functional Effects and Molecular Mechanisms of Subtype-Selective ER? and ER? Agonists in the Cardiovascular System.- Pathogenesis and Therapy of Rheumatoid Arthritis.- The Role of ER? and ER? in theProstate: Insights from Genetic Models and Isoform-Selective Ligands.- Preclinical Characterization of Selective Estrogen Receptor ? Agonists: New Insights into Their Therapeutic Potential.- Exploiting Nongenomic Estrogen Receptor-Mediated Signaling for the Development of Pathway-Selective Estrogen Receptor Ligands.

From the reviews: "This summation of a symposium discusses some of the new research developments and estrogen-receptor based therapies that are being tested in the laboratory and in current use. ... It is written for researchers, physician scientists, and those interested in estrogen receptor interactions at a molecular level. Hopefully, it can also stimulate interest in and future research by graduate students or clinical/basic researchers." (Amber R. Cooper, Doody's Review Service, January 2008)