Thymosins in Health and Disease

Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world-renowned authority on the thymus gland and the workings of the immune system, and co-discoverer of the thymosins.Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience.He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co-founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals.Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.

• Thymosin [alpha]1: the regulator of regulators? / Bonifazi Pierluigi [and others] Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1 / Claudia Matteucci [and others]Prothymosin [alpha] as robustness molecule against ischemic stress to brain and retina / Hiroshi Ueda [and others]Thymosin [beta]4 and its postranslational modifications / E. HannappelRepolymerization of actin from actin:thymosin [beta]4 complex induced by diaphanous related formins and gelsolin / Hans Georg Mannherz, Antonina Joanna Mazur, and Brigitte JockuschMultifunctionality of the [beta]-thymosin/WH2 module: G-actin sequestration, actin filament growth, nucleation, and severing / Clotilde Husson [and others]Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin [beta]4 in neoplastic diseases / Jian-Miao Liu [and others]Thymosin [beta]4 regulates migration of colon cancer cells by a pathway involving interaction with Ku80 / Czeslaw S. Cirniewski [and others]Progression of ocular sulfur mustard injury: development of a model system / Denise Milhorn [and others]Animal studies with thymosin [beta]4, a multifunctional tissue repair and regeneration peptide / Deborah Philp and Hynda K. KleinmanThymosin [beta]4 and cardiac repair / Santwana Shrivastava [and others]Thymosin [beta]4 facilitates epicardial neovascularization of the injured adult heart / Nicola Smart [and others]Thymosin [beta]4: a key factor for protective effects of eEPCs in acute and chronic ischemia / Rabea Hinkel [and others]Thymosin [beta]4: a candidate for treatment of stroke? / Daniel C. Morris [and others]Thymosin [beta]4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts / H. Paul Ehrlich and Sprague W. Hazard IIIThymosin [beta]4 in multiple myeloma: friend or foe / Jo Caers [and others]Thymosin alpha 1: past clinical experience and future promise / Cynthia Tuthill, Israel Rios, and Randy McBeathThymosin [alpha] 1 for treatment of hepatitis C virus : promise and proof / Kenneth E. ShermanThymalfasin in the treatment of hepatitis B and C / A. Chiancio and M. RizzettoImmunological modifications during treatment with thymosin [alpha]1 plus antiviral therapy in chronic hepatitis C / E. Grandini [and others]Thymosin [alpha]1 to harness immunity to pathogens after haploidentical hematopoietic thransplantation / Katia Perruccio [and others]Preclinical studies with IRX-2 and thymosin [alpha]1 in combination therapy / Paul H. Naylor and John W. HaddenCombination strategies for enhancing the efficacy of immunotherapy in cancer patients / Federica Moschella [and others]Thymosin [beta]4: structure, function, and biological properties supporting current and future clinical applications / David Crockford [and others]Thymosin [beta]4 and corneal wound healing: visions of the future / Gabriel Sosne [and others]Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin [beta]4 / Steven P. Dunn [and others]The effect of thymosin treatment of venous ulcers / G. Guarnera, A DeRosa, and R. CameriniInherited epidermolysis bullosa: past, present, and future / Jo-David FineA randomized, placebo-controlled, single and multiple dose study of intravenous thymosin [beta]4 in healthy volunteers / Dennis Ruff [and others]