Therapeutics of Natural and Synthetic Compounds in Protease-Induced Cancer

Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 40 years teaching and independent research experience in biochemistry, molecular physiology and cell biology. He has published over 110 original research articles, dozens of review articles and book chapters, and also edited fifteen books.

• A. General Aspects1. Therapeutic aspects of urokinase-plasminogen activator system in cancer2. The role of acetylcholinesterase in cancer development and possible therapeutic applications by natural and synthetic compounds.3. Influence of serine proteases on bone morphogenetic proteins: Insights for advancing treatment paradigm in breast cancer4. Structural insights of proteases in cancer therapy perspectivesB. Role of Synthetic Compounds5. Role of Boron containing synthetic compounds as serine proteases inhibitors in prostate cancer6. Exploring Synthetic and Natural Compounds for Cathepsin B-mediated Breast Cancer: Mechanisms and Therapy ResponsesC. Role of Natural Compounds7. Flavonoids containing phytochemicals as protease inhibitors in cancer chemoprevention8. Dietary proteases and their connection to cancer9. Natural compounds as potential cancer therapeutics: A focus on curcumin and resveratrol10. Snake venom proteases as potential cancer therapeutics11. Autophagy Inhibition with Plant-Derived Alkaloids in Cancer Treatment: From Molecular Mechanisms to Targeted Therapy12. From Naturally-sourced aspartic and metalloproteases inhibitors to therapeutic aspects of skin cancer13. Compounds of plant origin as therapeutics for serine protease implicated in colorectal cancer14. Plant peptides and proteins as protease inhibitors in breast cancer therapy15. Exploring the Potentials of Genistein, Lycopene, Ellagic acid as Protease Inhibitors in Cancer Therapeutics16. Modulation of serine proteases in liver cancer by quercetin - a therapeutic perspective17. Role of natural bioactive small molecules as inhibitors for cysteine proteases in cancer18. Natural compounds as inhibitors of MMPs19. A Comprehensive Overview of Epigallocatechin Gallate and Its Role in Human Osteosarcoma inhibition.20. Exploring the natural repository of serine protease inhibitors for cancer therapeuticsD. Protease inhibitors in Clinical Trials21. Inhibitors of matrix metalloproteinases in clinical trials22. Breast cancer therapeutics by protease inhibitors23. Clinical trials on the efficacy of anticancer protease inhibitors on breast, prostate, lung

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