Theranostics, Gallium-68, and Other Radionuclides

A Pathway to Personalized Diagnosis and Treatment

Inbunden, Engelska, 2012

Av Richard P. Baum, Frank Rösch, MD Baum, Richard P., Frank Rosch

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This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics – the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly.

Produktinformation

Utgivningsdatum2012-08-23
Mått155 x 235 x 37 mm
Vikt1 012 g
FormatInbunden
SpråkEngelska
SerieRecent Results in Cancer Research
Antal sidor578
Upplaga2013
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783642279935

Tillhör följande kategorier

Onkologi inom Medicin
Nuklearmedicin inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Medicinsk bildbehandling inom Medicin

From the contents: Ge-68/Ga-68 generators.- Automation strategies in Ga-68 radiopharmaceutical preparations.- Post-processing via cation exchange cartridges.- Gallium-68 generator integrated system: elution – purification - concentration integration.- Purification and labelling strategies for 68Ga from 68Ge/68Ga generator eluate.- 67Ga and 68Ga purification studies.- The diversity of [68Ga]Ga-based imaging agents.- Nanoparticles and phage display selected peptides for imaging and therapy of cancer.- “Click” cyclized gallium-68 labeled peptides for molecular imaging and therapy: Synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system.- Early experience with 68Ga-DOTATATE preparation .- 68Ga-radiopharmaceuticals for PET imaging of infection and inflammation.- 68Ga-labeled bombesin analogs for receptor mediated imaging.- A novel 68Ga-labelled pteroic acid-based PET tracer for tumour imaging via the folate receptor.- Measurement of protein synthesis: In vitro comparison of 68Ga-DOTA-puromycin, [3H]tyrosine and 2-fluoro-[3H]tyrosine.- Hypoxia imaging agents labeled with positron emitters.- Lu-177/Y-90 intermediate affinity monoclonal antibodies targeting EGFR and HER2/c-neu: preparation and preclinical evaluation.- Divergent role of 68Ga labeled somatostatin analogs in the work-up of patients with NETs.- Differential uptake of 68Ga-DOTATOC and 68Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumours.

From the reviews: "The general themes of this book (theranostics and peptide receptor-targeted radiotherapy) derive from evolving successes in the use of generator-produced 68Ga for molecular imaging of disease. ... This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in 68Ga and peptide receptor radionuclide therapy-based theranostics for preclinical and emerging clinical applications." (Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013)