Häftad, Engelska, 2027

The Transcription Factor NRF2

Biology, Disease and Translational Opportunities

Av Narendra Kumar Sharma, Yasmin Ahmad

2429 kr

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Beskrivning

The Transcription Factor NRF2: Biology, Disease and Translational Opportunities offers a detailed and authoritative reference on NRF2, a key regulator of cellular defence against oxidative stress. This book thoroughly examines the latest research, from molecular mechanisms to clinical applications, highlighting NRF2’s essential function in cell protection, disease prevention, and its promise as a therapeutic target. The book opens with an introduction to NRF2 and its role in cellular homeostasis before exploring its molecular structure, regulation and signalling mechanisms. Its antioxidant response is then discussed, followed by its impact on inflammation, autophagy, and resistance to environmental and chemical stresses. Later chapters cover NRF2’s role in cancer, neurodegenerative, cardiovascular, autoimmune, and metabolic diseases. Cutting-edge techniques are also provided, including AI-based and systems biology tools. Case studies emphasize translational potential and therapeutic development.

The Transcription Factor NRF2: Biology, Disease and Translational Opportunities equips researchers, clinicians, and advanced students with critical knowledge to understand NRF2’s multifaceted functions and therapeutic potential. It serves as an essential guide for advancing research and strategies targeting NRF2 in a diverse array of medical conditions, and is an ideal reference for those working across cell biology, molecular biology, biomedicine and related fields.

Explores NRF2 as a therapeutic target across a diverse range of diseases
Considers the dual nature of NRF2 as both detrimental and beneficial in various disease states
Highlights clinical applications and drug development strategies
Investigates the latest experimental techniques and AI-based tools for studying NRF2

Produktinformation

Utgivningsdatum: 2027-03-01
Mått: 191 x 235 x undefined mm
Format: Häftad
Språk: Engelska
Antal sidor: 400
Förlag: Elsevier Science
ISBN: 9780443454721

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Mer information

Dr. Narendra Kumar Sharma is currently an Assistant Professor in the Department of Biosciences and Biotechnology at Banasthali Vidyapith, Rajasthan, India. He has a PhD from the Defence Institute of Physiology and Allied Sciences (DRDO) and completed his post-doctoral training at the Guangzhou Institutes of Biomedicine and Health (GIBH) in China and at the Federal University of Sao Paulo (UNIFESP) in Brazil. He has more than eight years of teaching and research experience. He has published more than 30 research articles in peer-reviewed international journals, has authored and edited books, and has presented his research at various international conferences in India, Brazil, China, USA, and Germany. He has also been awarded. He has been awarded several prestigious awards such as the Dr. T S Vasundhara Memorial Best Paper Award and the Young Scientist and Best Innovator Award by Microbiologist Society of India.Dr. Yasmin Ahmad is currently a Senior Scientist at the Peptide and Proteomics Division of DIPAS, India. She earned her Ph.D. in Analytical Chemistry from Aligarh Muslim University (AMU), where she also completed a prestigious Senior Research Fellowship under CSIR. Dr. Ahmad has published over 45 original research articles in prestigious peer reviewed journals. Her impactful research has garnered recognition in the form of numerous awards, such as the Surg. Rear Admiral M.S. Malhotra Research Prize (2013), the Dr. T.S. Vasundhara Memorial Best Paper Award (2015), and the VIRA Outstanding Scientist Award in Analytical Chemistry (2017), Smt. Kusum Sharma Award for a Young Woman Scientist, IABS (2017), Laboratory Scientist of the year (2021), Marie Curie Excellence Award (2022). In addition to her research, Dr. Ahmad serves on the editorial boards of several leading journals, including the “Journal of Translational Proteomics Research and “World Journal of Pharmacy and Pharmaceutical Sciences.

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