The Science, Etiology and Mechanobiology of Diabetes and its Complications

Professor Amit Gefen received the B.Sc. in Mechanical Engineering and M.Sc. and Ph.D. in Biomedical Engineering from Tel Aviv University in 1994, 1997, and 2001, respectively. During 2002-2003 he was a post-doctoral fellow at the University of Pennsylvania, USA. He is currently a Full Professor with the Department of Biomedical Engineering at the Faculty of Engineering of Tel Aviv University and the Herbert J. Berman Chair in Vascular Bioengineering. Prof. Gefen has also been the Head of the Ela Kodesz Institute for Medical Engineering and Physical Sciences at Tel Aviv University. The research interests of Prof. Gefen are in studying normal and pathological effects of biomechanical factors on the structure and function of cells, tissues and organs, with emphasis on applications in chronic wound research. He is the Editor-in-Chief of Clinical Biomechanics (published by Elsevier), and has also edited several books and several Special Issues in journals such as the Annals of Biomedical Engineering, Journal of Biomechanics, Computer Methods in Biomechanics and Biomedical Engineering and more. Recently, Prof. Gefen chaired the Etiology expert panel for development of the International Pressure Ulcer Prevention & Treatment Guidelines (2019) and also chaired the global panel of experts who developed the International Consensus Document for Device-related Pressure Ulcers, published by the Journal of Wound Care (2020).

• 1. Heel ulcers in patients with diabetes Michael Clark2. Diabetic foot ulcers and their wound Management Norihiko Ohura, Katsuya Hisamichi3. Computational modeling of the plantar tissue stresses induced by the clinical practice of off-loading of the diabetic footHadar Shaulian, Amit Gefen, Alon Wolf4. Modeling effects of sustained bodyweight forces on adipose tissue microstructures and adipocytes in diabesityMaayan Lustig, Golan Amrani, Adi Lustig, Liran Azaria, Raz Margi, Yoni Koren, Avraham Kolel, Nurit Bar-Shai, Avior Exsol, Maya Atias, Amit Gefen5. Mechanisms underlying vascular stiffening in obesity, insulin resistance, and type 2 diabetesMichael A. Hill, Yan Yang, Zhe Sun, Liping Zhang, James R. Sowers6. Pathomechanics of diabetic foot ulceration: revisiting plantar shear and temperatureMetin Yavuz7. Novel technologies for detection and prevention of diabetic foot ulcersNeil D. Reeves, Bill Cassidy, Caroline A. Abbott, Moi Hoon Yap8. The role of tissue biomechanics in improving the clinical management of diabetic foot ulcersPanagiotis Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam9. The mechanobiology of adipocytes in the context of diabetes: much more than a fat depotShirley L. Yitzhak-David, Daphne Weihs10. Optical Coherence Tomography to determine and visualize pathological skin structure changes caused by diabetesRaman Maiti, Roger Lewis, Daniel Parker, Matt J. Carré11. Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cellsTasneem Bouzid, Jung Yul Lim12. Clinical complications of tendon tissue mechanics due to collagen crosslinking in diabetesJennifer A. Zellers, Jeremy D. Eekhoff, Simon Y. Tang, Mary K. Hastings, Spencer P. Lake13. A phenomenological dashpot model for morphoelasticity for the contraction of scarsF.j. Vermolen14. Mechanobiology of diabetes and its complications: from mechanisms to effective mechanotherapiesChenyu Huang, Rei Ogawa15. Application of tissue mechanics to clinical management of risk in the diabetic footDaniel Parker, Farina Hashmi16. Bone carriers in diabetic foot osteomyelitisCristian Nicoletti17. Vascular mechanobiology and metabolismSarah Basehore, Jonathan Garcia, Alisa Morss Clyne18. Effect of type 2 diabetes on bone cell behaviorRachana Vaidya, Anna Church, Lamya Karim19. What makes a good device for the diabetic footEvan Call, Darren F. Groberg, Nick Santamaria20. Allostasis: a conceptual framework to better understand and prevent diabetic foot ulcersLaurel Tanner, Craig Oberg, Evan Call21. Footwear for persons with diabetes at high risk for foot ulceration: offloading, effectiveness, and costs Sicco A. Bus22. Compounding effects of diabetes in vessel formation in microvessel fragmentebased engineered constructsOmar Mourad, Blessing Nkennor, Sara S. Nunes23. Dressing selection challenges in diabetic foot local treatmentPaulo Alves, Tania Manuel, Nuno Mendes, Emília Ribeiro, Anabela Moura