M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease. George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.Dr. Betty Diamond graduated with a BA from Harvard University and an MD from Harvard Medical School. Dr. Diamond has headed the rheumatology divisions at Albert Einstein School of Medicine and at Columbia University Medical Center. She also directed the Medical Scientist Training Program at Albert Einstein School of Medicine for many years. She is currently director of the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research and director of the PhD and MD/PhD programs of the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Dr. Diamond is a fellow of the American Association for the Advancement of Science (AAAS) and a member of the National Academy of Medicine and the National Academy of Sciences.

• Section 1: Immunologic Basis of Autoimmunity1. Prelude: Historical introduction to autoimmunity and autoimmune disease2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity3. General Features of Autoimmune Diseases (same title new contributor, new content)4. Antigen Presentation, Dendritic Cells, and Autoimmunity5. T cells and their subsets6. Role of Th1 Th2 Th17 Cells in Autoimmunity7. Tolerance and Autoimmunity: T Cells8. Regulatory T Cells9. B Cells and Autoimmunity10. Immunological memory T cells11. Immunological memory B cells12. Apoptotic Cells as a Source of Autoantigens13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes14. Functional Effects of Autoantibodies15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes17. HLA Genetics and Autoimmunity18. Non HLA Genetics19. AIRE related Autoimmunity20. Immune Deficiencies and Autoimmunity21. Infections and Autoimmunity22. Noninfectious Environmental Agents and Autoimmunity23. Sex, Pregnancy and Autoimmunity24. Animal Models of Autoimmune DiseaseSection 2: Multisystem Diseases25. Systemic Lupus Erythematosus26. Systemic Sclerosis, Scleroderma27. Antiphospholipid Syndrom28. Sjogren Syndrome29. Rheumatoid Arthritis30. Spondyloarthritis and Chronic Idiopathic Arthropathies31. Myositis32. Thyroid Disease33. Type 1 Diabetes34. Adrenalitis35. Polyendocrine Syndromes36. Gastritis and Pernicious Anemia37. Hypophysitis38. Hemolytic Anemia39. Thrombocytopenic Purpura40. Neutropenia41. Aplastic Anemia42. Clotting Disorders43. Multiple Sclerosis44. Peripheral Neuropathy45. Myasthenia Gravis46. Ocular Disease47. Inner Ear Disease48. Celiac Disease49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease50. Chronic Hepatitis51. Primary Billiary Cirrhosis52. Primary Sclerosing Cholangitis53. Pancreatitis54. Bullous Skin Diseases: Pemphigus and Pemphigoid55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis57. Orchitis and Male Infertility58. Oophoritis59. Rheumatic Heart Disease60. Myocarditis and Dilated Cardiomyopathy61. Necrotizing Arteritis and Small Vessel Vasculitis62. Large and Medium Vessel Vasculitides63. Autoimmune Disorders of the Lung64. Paraneoplastic Diseases65. Antibody-Associated Neurological Diseases66. Autoinflammatory and other Related Diseases67. Autoinflammatory diseases and autoimmune responses to tumors68. COVIDSection 3: Diagnosis, Prevention, and Therapy69. Autoantibody Assays, Testing, and Standardization70. Prediction of Autoimmune Disease71. Emerging Therapies for Autoimmune Diseases72. Postlude

"...provides comprehensive information on autoimmune diseases, covering the basics to clinical practice. Authored by over 200 experts on the subject, the purpose of this book is to provide in-depth and up-to-date information on the basics and clinical aspects of autoimmune diseases.... emphasizes the '3 Ps: Precision, Prediction, and Prevention,' aiming to present this collection as an authoritative resource on autoimmune diseases. The target groups are rheumatologists, allergists, and clinical immunologists, as well as fellows-in-training and scientists interested in autoimmune diseases.... This comprehensive collection includes every autoimmune disease and related concept, formatted as two volumes divided into 11 parts and 80 chapters,... [which] contain various colorful visual aids, which are essential teaching tools, especially in the presentation of immune-related topics. The present edition continues the legacy of being a single authoritative resource of information on autoimmune diseases." ©Doody's Book Review Service, 2025, Massoud Mahmoudi, DO, PhD (University of California San Francisco)

M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease. George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.Dr. Betty Diamond graduated with a BA from Harvard University and an MD from Harvard Medical School. Dr. Diamond has headed the rheumatology divisions at Albert Einstein School of Medicine and at Columbia University Medical Center. She also directed the Medical Scientist Training Program at Albert Einstein School of Medicine for many years. She is currently director of the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research and director of the PhD and MD/PhD programs of the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Dr. Diamond is a fellow of the American Association for the Advancement of Science (AAAS) and a member of the National Academy of Medicine and the National Academy of Sciences.

• Section 1: Immunologic Basis of Autoimmunity1. Prelude: Historical introduction to autoimmunity and autoimmune disease2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity3. General Features of Autoimmune Diseases (same title new contributor, new content)4. Antigen Presentation, Dendritic Cells, and Autoimmunity5. T cells and their subsets6. Role of Th1 Th2 Th17 Cells in Autoimmunity7. Tolerance and Autoimmunity: T Cells8. Regulatory T Cells9. B Cells and Autoimmunity10. Immunological memory T cells11. Immunological memory B cells12. Apoptotic Cells as a Source of Autoantigens13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes14. Functional Effects of Autoantibodies15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes17. HLA Genetics and Autoimmunity18. Non HLA Genetics19. AIRE related Autoimmunity20. Immune Deficiencies and Autoimmunity21. Infections and Autoimmunity22. Noninfectious Environmental Agents and Autoimmunity23. Sex, Pregnancy and Autoimmunity24. Animal Models of Autoimmune DiseaseSection 2: Multisystem Diseases25. Systemic Lupus Erythematosus26. Systemic Sclerosis, Scleroderma27. Antiphospholipid Syndrom28. Sjogren Syndrome29. Rheumatoid Arthritis30. Spondyloarthritis and Chronic Idiopathic Arthropathies31. Myositis32. Thyroid Disease33. Type 1 Diabetes34. Adrenalitis35. Polyendocrine Syndromes36. Gastritis and Pernicious Anemia37. Hypophysitis38. Hemolytic Anemia39. Thrombocytopenic Purpura40. Neutropenia41. Aplastic Anemia42. Clotting Disorders43. Multiple Sclerosis44. Peripheral Neuropathy45. Myasthenia Gravis46. Ocular Disease47. Inner Ear Disease48. Celiac Disease49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease50. Chronic Hepatitis51. Primary Billiary Cirrhosis52. Primary Sclerosing Cholangitis53. Pancreatitis54. Bullous Skin Diseases: Pemphigus and Pemphigoid55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis57. Orchitis and Male Infertility58. Oophoritis59. Rheumatic Heart Disease60. Myocarditis and Dilated Cardiomyopathy61. Necrotizing Arteritis and Small Vessel Vasculitis62. Large and Medium Vessel Vasculitides63. Autoimmune Disorders of the Lung64. Paraneoplastic Diseases65. Antibody-Associated Neurological Diseases66. Autoinflammatory and other Related Diseases67. Autoinflammatory diseases and autoimmune responses to tumors68. COVIDSection 3: Diagnosis, Prevention, and Therapy69. Autoantibody Assays, Testing, and Standardization70. Prediction of Autoimmune Disease71. Emerging Therapies for Autoimmune Diseases72. Postlude

"...provides comprehensive information on autoimmune diseases, covering the basics to clinical practice. Authored by over 200 experts on the subject, the purpose of this book is to provide in-depth and up-to-date information on the basics and clinical aspects of autoimmune diseases.... emphasizes the '3 Ps: Precision, Prediction, and Prevention,' aiming to present this collection as an authoritative resource on autoimmune diseases. The target groups are rheumatologists, allergists, and clinical immunologists, as well as fellows-in-training and scientists interested in autoimmune diseases.... This comprehensive collection includes every autoimmune disease and related concept, formatted as two volumes divided into 11 parts and 80 chapters,... [which] contain various colorful visual aids, which are essential teaching tools, especially in the presentation of immune-related topics. The present edition continues the legacy of being a single authoritative resource of information on autoimmune diseases." ©Doody's Book Review Service, 2025, Massoud Mahmoudi, DO, PhD (University of California San Francisco)

M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease. George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.Dr. Betty Diamond graduated with a BA from Harvard University and an MD from Harvard Medical School. Dr. Diamond has headed the rheumatology divisions at Albert Einstein School of Medicine and at Columbia University Medical Center. She also directed the Medical Scientist Training Program at Albert Einstein School of Medicine for many years. She is currently director of the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research and director of the PhD and MD/PhD programs of the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Dr. Diamond is a fellow of the American Association for the Advancement of Science (AAAS) and a member of the National Academy of Medicine and the National Academy of Sciences.

• Section 1: Immunologic Basis of Autoimmunity1. Prelude: Historical introduction to autoimmunity and autoimmune disease2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity3. General Features of Autoimmune Diseases (same title new contributor, new content)4. Antigen Presentation, Dendritic Cells, and Autoimmunity5. T cells and their subsets6. Role of Th1 Th2 Th17 Cells in Autoimmunity7. Tolerance and Autoimmunity: T Cells8. Regulatory T Cells9. B Cells and Autoimmunity10. Immunological memory T cells11. Immunological memory B cells12. Apoptotic Cells as a Source of Autoantigens13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes14. Functional Effects of Autoantibodies15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes17. HLA Genetics and Autoimmunity18. Non HLA Genetics19. AIRE related Autoimmunity20. Immune Deficiencies and Autoimmunity21. Infections and Autoimmunity22. Noninfectious Environmental Agents and Autoimmunity23. Sex, Pregnancy and Autoimmunity24. Animal Models of Autoimmune DiseaseSection 2: Multisystem Diseases25. Systemic Lupus Erythematosus26. Systemic Sclerosis, Scleroderma27. Antiphospholipid Syndrom28. Sjogren Syndrome29. Rheumatoid Arthritis30. Spondyloarthritis and Chronic Idiopathic Arthropathies31. Myositis32. Thyroid Disease33. Type 1 Diabetes34. Adrenalitis35. Polyendocrine Syndromes36. Gastritis and Pernicious Anemia37. Hypophysitis38. Hemolytic Anemia39. Thrombocytopenic Purpura40. Neutropenia41. Aplastic Anemia42. Clotting Disorders43. Multiple Sclerosis44. Peripheral Neuropathy45. Myasthenia Gravis46. Ocular Disease47. Inner Ear Disease48. Celiac Disease49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease50. Chronic Hepatitis51. Primary Billiary Cirrhosis52. Primary Sclerosing Cholangitis53. Pancreatitis54. Bullous Skin Diseases: Pemphigus and Pemphigoid55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis57. Orchitis and Male Infertility58. Oophoritis59. Rheumatic Heart Disease60. Myocarditis and Dilated Cardiomyopathy61. Necrotizing Arteritis and Small Vessel Vasculitis62. Large and Medium Vessel Vasculitides63. Autoimmune Disorders of the Lung64. Paraneoplastic Diseases65. Antibody-Associated Neurological Diseases66. Autoinflammatory and other Related Diseases67. Autoinflammatory diseases and autoimmune responses to tumors68. COVIDSection 3: Diagnosis, Prevention, and Therapy69. Autoantibody Assays, Testing, and Standardization70. Prediction of Autoimmune Disease71. Emerging Therapies for Autoimmune Diseases72. Postlude

"...provides comprehensive information on autoimmune diseases, covering the basics to clinical practice. Authored by over 200 experts on the subject, the purpose of this book is to provide in-depth and up-to-date information on the basics and clinical aspects of autoimmune diseases.... emphasizes the '3 Ps: Precision, Prediction, and Prevention,' aiming to present this collection as an authoritative resource on autoimmune diseases. The target groups are rheumatologists, allergists, and clinical immunologists, as well as fellows-in-training and scientists interested in autoimmune diseases.... This comprehensive collection includes every autoimmune disease and related concept, formatted as two volumes divided into 11 parts and 80 chapters,... [which] contain various colorful visual aids, which are essential teaching tools, especially in the presentation of immune-related topics. The present edition continues the legacy of being a single authoritative resource of information on autoimmune diseases." ©Doody's Book Review Service, 2025, Massoud Mahmoudi, DO, PhD (University of California San Francisco)