The Osteoporosis Primer

Häftad, Engelska, 2000

AvJanet E. Henderson,David Goltzman,Montreal) Henderson, Janet E. (McGill University,Montreal) Goltzman, David (McGill University

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Osteoporosis is one of the leading causes of morbidity and mortality amongst the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organised into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and, finally, how all of these relate to the prevention, diagnosis and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This will be an essential introduction for individuals working on osteoporosis including students and doctors considering a career related to metabolic bone disease, physicians in general practice, geriatricians, rheumatologists, and endocrinologists.

Produktinformation

Utgivningsdatum2000-08-24
Mått176 x 247 x 23 mm
Vikt750 g
FormatHäftad
SpråkEngelska
Antal sidor388
FörlagCambridge University Press
ISBN9780521644464

Tillhör följande kategorier

Muskuloskeletala sjukdomar inom Medicin
Särskilda hälsotillstånd inom Hälsa och familj
Endokrinologi inom Medicin
Ortopedi och frakturer inom Medicin

Preface Janet E. Henderson and David Goltzman; Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale; 2. The role of osteoblasts Jane E. Aubin; 3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson; 4. Bone matrix proteins Marc D. McKee and Jaro Sodek; 5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson; 6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy; 7. Vitamin D metabolism Marielle Gascon-Barre; 8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse; Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman; 10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole; 11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll; 12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan; 13. Osteoporosis in children Frank Rauch and Francis H. Glorieux; Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz; 15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D'Amour; 16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla; Part IV. Clinical Aspects of Osteoporosis; 17. Epidemiology Jaques Brown; 18. Biochemical markers of bone turnover David Hanley; 19. Radiologic assessment of osteoporosis Jaqueline C. Hodge; 20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski; 21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou; 22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay; 23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar; 24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback; 25. PTH peptides as anabolic agents in bone Anthony B. Hodsman; 26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.

'I really enjoyed tying together the cell biology and the basis of the current treatments and potential therapeutic interventions. I found that I knew a lot more about bone cell physiology, bone turnover and cell signalling by the end of the section. … The book succeeds as an introductory text on metabolic bone disease and provides insight into the complexity of the subject without becoming overwhelming.' Gerontology