The multitasking molecular chaperone Hsp60

Francesco Cappello is Full Professor of Anatomy and Histology at the University of Palermo, Palermo, Italy. He is also President of the Italian Society of Experimental Biology, Life member of the Cell Stress Society International and former Senior Editor of Cell Stress and Chaperones. He has been nominated “Adjunct Professor” at the Temple University of Philadelphia (PA, USA) and at the University of Texas Medical Branch of Galveston (TX, USA). He has authored more than 300 scientific papers. Everly Conway de Macario is Adjunct Professor at the School of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA. She has written 320 articles, authored 1 book and edited 8 books. Dr. Conway de Macario’s research interests include the development of the concept of sick chaperone or chaperonopathy as a factor contributing to the ageing process and disease, elucidation of the entire set of hsp70 genes in the human genome, and characterization of the whole complement of cct-Hsp60 genes in the human genome. Alberto JL Macario is Adjunct Professor at the School of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA. He has authored 380 articles, is the author of 1 book, and editor of 7 books. Dr. Macario is also Group Leader at the Euro-Mediterranean Institute of Science and Technology, Palermo, Italy. His current interests are chaperonopathies pertaining to Hsp60, Hsp10, and CCT genes/proteins.

• The chaperone system and its diseases: Introductory overview focusing on Hsp60Physical and biochemical properties of the molecular chaperone Hsp60The spectrum of human Hsp60 genetic variants and associated chaperonopathiesHsp60 in inflammation and autoimmunityHsp60 and carcinogenesisHsp60 involvement in articular cartilage tissue homeostasis and pathogenesisHsp60 and skeletal muscle diseasesHsp60 and cardiovascular diseasesHsp60 in physiology and pathophysiology of the respiratory systemHsp60 and diseases of the digestive systemThe chaperone system and the pathophysiology of the urogenital apparatus: Hsp60 rolesHsp60 and nervous system development and diseasesHsp60 and pathophysiology of the neuroendocrine systemHsp60 and artificial intelligence