The Molecular Biology of Arrestins

• Part I: Perspective - The Duality of Arrestin Function1. Arrestins Come of Age: A Personal Historical PerspectivePart II: The Molecular Biology of Arrestins 2. True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal 3. Structural Determinants of Arrestin Functions 4. Arrestins: Role in the Desensitization, Sequestration and Vesicular Trafficking of G Protein-Coupled Receptors 5. Arrestins as Regulators of Kinases and Phosphatases 6. ß-Arrestins: Modulators of Small GTPase Activation and Function 7. Arrestins and Protein Ubiquitination 8. Arrestins in Actin Reorganization and Cell MigrationPart III: The Physiological Roles of Arrestins 9. The Role of Arrestins in Development 10. The Role of Arrestins in Visual and Disease Processes of the Eye 11. b-Arrestins in the Central Nervous System 12. Arrestins in the Cardiovascular System 13. Arrestins in Bone 14. b-Arrestins in the Immune System 15. The Role of b-Arrestins in Cancer 16. Arrestins in Metabolic RegulationPart IV: The Future - The Potential for Arrestin-based Therapeutics 17. Systems Analysis of Arrestin Pathway Functions 18. Arrestin Pathways as Drug Targets

Praise for the series:"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal