The Human Frontal Lobes

Bruce L. Miller, MD, is the A. W. and Mary Margaret Clausen Distinguished Professor of Neurology at the University of California, San Francisco (UCSF), and Director of the UCSF Memory and Aging Center. Dr. Miller is a behavioral neurologist focused on dementia, with special interests in brain-behavior relationships as well as the genetic and molecular underpinnings of disease. He currently conducts research on frontotemporal dementia, oversees a program on healthy aging, and helps lead two privately funded research consortia. Dr. Miller is a recipient of the Potamkin Prize from the American Academy of Neurology, the Raymond D. Adams Lectureship from the American Neurological Association, the J. Elliot Royer Award from the San Francisco Neurological Society, the UCSF Annual Faculty Research Lectureship in Clinical Science, and the Gene D. Cohen Research Award in Creativity and Aging from the National Center for Creative Aging, among many other honors. With more than 700 scientific publications, Dr. Miller has served since 1984 as Scientific Director of the John Douglas French Alzheimer’s Foundation. He is a member of the National Academy of Medicine.Jeffrey L. Cummings, MD, ScD, is Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada, and Cleveland, Ohio. He is the Camille and Larry Ruvo Chair for Brain Health at the Cleveland Clinic Neurological Institute and Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. A leading authority on Alzheimer's disease, Dr. Cummings is interested in clinical trials, developing new therapies for brain diseases, and the interface of neuroscience and society. He is a recipient of the Edward Henderson Award from the American Geriatrics Society, the Research Award from the John Douglas French Alzheimer’s Foundation, the Ronald and Nancy Reagan Research Institute Award from the Alzheimer’s Association, the Distinguished Scientist Award from the American Association for Geriatric Psychiatry, and the Lifetime Achievement Award from the Society for Behavioral and Cognitive Neurology, among many other honors. Dr. Cummings has more than 700 scientific publications and is a past president of the Behavioral Neurology Society and the American Neuropsychiatric Association.

• I. Neuroanatomy and Neurochemistry1. The Human Frontal Lobes: An Introduction, Bruce L. Miller and Jeffrey L. Cummings2. The Mesocortical Dopaminergic System, Billy T. Chen and Antonello Bonci3. The Dorsolateral and Cingulate Cortex , James R. Bateman and Daniel I. Kaufer4. The Orbitofrontal Cortex and the Insula, Eun-Joo Kim, Jennifer Ogar, and Maria Luisa Gorno-Tempini5. Structural and Functional Asymmetries of the Human Frontal Lobes, Daniel H. Geschwind and Marco Iacoboni6. Gross Morphology and Architectonics, Helmut Heinsen and Lea Tenenholz GrinbergII. Assessment: Neuropsychology and Behavior7. The Frontal Lobes and Executive Control, Adam Gazzaley, Taraz G. Lee, and Mark D’Esposito8. Bedside Frontal Lobe Testing, Adam M. Staffaroni, Melanie L. Stephens, and Joel H. Kramer9. The Prefrontal Cortex and Human Memory, Nick Diamond and Brian Levine10. Language and Frontal Cortex, Marlís González-Fernández and Argye E. Hillis11. Self-Awareness and Frontal Lobe Networks, Virginia E. Sturm, Alice Y. Hua, and Howard J. Rosen12. Decision-Making Capacity and Frontal Lobe Dysfunction, Sarah M. Hooper and Winston Chiong13. Socioemotional Functioning and Frontal Lobe Injury, Katherine P. Rankin, Kelly Gola, and Tracy L. Jerard14. Salience Networks: Magnetic Resonance Imaging Interrogation of Self-Concepts in Dementia, Winston ChiongIII. Neurological DiseasesSection A: FTD and Related Disorders15. Clinical Aspects of Frontotemporal Dementia, David C. Perry and Bruce L. Miller16. Progressive Supranuclear Palsy, Corticobasal Degeneration, and the Frontal Cortex, Anne-Catherine Vijverman, Maria Carmela Tartaglia, and Anthony E. Lang17. Neuropathology of Frontotemporal Dementias, Nigel J. Cairns, David J. Irwin, Vivianna M. Van Deerlin, Virginia M.-Y. Lee, and John Q. Trojanowski18. Frontotemporal Dementia Neurogenetics, Leonel T. TakadaSection B: Other Disorders19. Normal Aging of the Frontal Lobes, Brianne Bettcher20 . Vascular Cognitive Impairment: Executive Dysfunction in the Era of the Human Brain Connectome, Helena C. Chui and Liliana Ramirez Gomez21. White Matter Diseases of the Frontal Lobes, Christopher M. Filley22 . Parkinson’s Disease, Parkinson’s Disease with Dementia, and Dementia with Lewy Bodies, Jee Bang, Sharon J. Sha, and Katherine L. Possin23. Traumatic Brain Injury, Judith Aharon-PeretzIV. Neuropsychiatric Disorders24. Prefrontal Cortical Dysfunction in Schizophrenia: Clinical Implications and Novel Treatment Development, Daniel Fulford, Joshua D. Woolley, and Sophia Vinogradov25. Mania and the Frontal Lobes, Mary G. De May and Bruce L. Miller26. Obsessive–Compulsive Disorder, Edwin H. Rodriguez and Carol A. Mathews27 . Depression and the Frontal Lobes, Ira Lesser, Julia Chung, and Weiguo Zhu28. Apathy, Georges Naasan29 . Frontal Lobe Seizures, Frontal Cortex, and Dissociative States, Anli Liu and Orrin Devinsky30 . The Role of the Frontal Lobes in Antisocial and Aggressive Behavior: Review of the Research and Legal Implications, Annette L. Ermshar and Kyle Brauer BooneV . Treatment31. Neurosurgical Treatments for Psychiatric Disorders, Simon Ducharme, Darin D. Dougherty, and Bruce H. Price32 . Clinical Trials in Frontotemporal Lobar Degeneration, Gabriel C. Léger, Sarah J. Banks, and Jeffrey L. CummingsIndex

"A comprehensive, well-organized, and authoritative book. Prior editions have been on the required reading lists for trainees and practitioners in behavioral neurology, neuropsychiatry, neuropsychology, and cognitive neuroscience. In the third edition, the editors have reorganized the material and added a variety of new topics, including frontal systems dysfunction in a number of psychiatric disorders and expanded coverage of treatment. Miller and Cummings have mentored a generation of clinicians and scientists toward a nuanced understanding of frontal systems function and dysfunction. This book brings their passion for the subject to a new level of sophisticated scholarship."--Brad Dickerson, MD, Tom Rickles Chair in Progressive Aphasia Research and Director, Frontotemporal Disorders Unit, Massachusetts General Hospital; Associate Professor of Neurology, Harvard Medical School"Provides comprehensive coverage of frontal lobe neuroanatomy, neurochemistry, and neuropsychology, with an emphasis on the clinical presentation of and state-of-the-art treatments for frontal dysfunction across neurological and psychiatric syndromes. The editors--major figures in behavioral neurology and intellectual descendants of D. Frank Benson--have assembled an incredibly strong cast of contributors to bring this work to fruition. The enormous scope is complemented by critical depth in each chapter; the density of novel material shows how much has been learned over the last decade."--Robert M. Bilder, PhD, ABPP-CN, Michael E. Tennenbaum Family Professor of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles"It wasn’t long ago that scientists and clinicians considered the frontal lobes an enigma and could teach only vaguely about their functions. The fresh and contemporary third edition of this acclaimed work provides readers with succinct critical analyses of newly discovered mechanisms and functions of the frontal lobes. This book can serve as a core text for advanced students in cognitive and clinical neuroscience who need to acquire foundational principles in frontal lobe investigation and patient management. With up-to-date coverage of imaging; neuropsychiatric disorders; genetics; treatment approaches; and networks underlying salience, social behavior, and apathy, it will also enable seasoned scientists and clinicians to stay current with 21st-century frontal lobe neuroscience breakthroughs."--Paul J. Eslinger, PhD, Professor of Neurology, Neural and Behavioral Sciences, and Radiology, Penn State Hershey Medical Center and College of Medicine-The book brings together an outstanding list of researchers to update our current knowledge of the anatomy, behavioral functioning, and disease states of the frontal lobes….This continues to be an excellent resource on the frontal lobes. The new chapters are relevant to clinical practice and research. The book also has a much more integrated approach across the book, with neuroanatomy, neurochemistry, neuropsychology, neurogenetics, and neuroimaging. This edition is sufficiently updated on current issues in the field [and] is a worthwhile replacement of the previous edition. *****!--Doody's Review Service, 2/23/2018