The Hormonal Treatment of Endometriosis and Adenomyosis

Antonino Simone Laganà, MD, PhD, is an Assistant Professor (Researcher type B) in Obstetrics and Gynecology at the Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo (Palermo, Italy). He is the Coordinator of the Special Interest Group for Endometriosis and Endometrial Disorders (SIGEED) of the European Society of Human Reproduction and Embryology (ESHRE). He was trained in obstetric/gynecological ultrasound at the Altamedica Main Centre in Rome (Italy), he did his master’s in “Gynecological Minimally Invasive and Robotic Surgery” at the University of Pisa (Italy), PhD in “Medical and Surgical Biotechnologies” at the University of Messina (Italy), and developed an intensive training in minimally invasive gynecological surgery (high-volume advanced laparoscopy, hysteroscopy) at the Univerzitetni Klinični Center Ljubljana (Slovenia), during the Subspecialist Training Programme (Fellowship) in Reproductive Medicine (according to the criteria of the European Society of Human Reproduction, ESHRE, and Embryology and European Board and College of Gynecology and Obstetrics, EBCOG). His research interests include endometriosis, reproductive immunology, infertility, gynecological endocrinology, laparoscopy, and hysteroscopy. He is the author of more than 440 papers published in PubMed-indexed international peer-reviewed journals, and his presence is often requested as an invited speaker at international congresses. He is currently an editor of high-impact journals, including Scientific Reports, the Journal of Minimally Invasive Gynecology, Journal of Ovarian Research, Gynecologic and Obstetric Investigation, and many others. He is habilitated as Full Professor in Italy for Gynecology and Obstetrics.Antoine Naem is a medical doctor who graduated from the Faculty of Medicine of Damascus University, in Damascus, Syria. Dr. Naem is currently working as a research assistant at Bethesda Hospital Duisburg (Duisburg, Germany) in the department of obstetrics, gynecology, gynecologic oncology, and senology. Dr. Naem was awarded a scholarship from the German Academic Exchange Service (DAAD) for the academic years 2023-2024. The research interests of Dr. Naem are focused on the clinical and surgical management of endometriosis, especially bowel and diaphragmatic endometriosis. Dr. Naem is a member of the young team of the European Endometriosis League (EEL), and he is heavily involved in its educational events. Dr. Naem has authored more than 30 PubMed-indexed publications and contributed to two books in the field of endometriosis. Dr. Naem is an editorial board member of the Journal of Ovarian Research, PLoS ONE, BMC Women's Health, and Frontiers in Reproductive Health.

• 1. The hormonal regulation of endometriosis and adenomyosis2. The in-vitro and in-vivo effects of the hormonal agents on the endometriotic and adenomyotic lesions3. The intraoperative morphological changes of the endometriotic lesions following the prolonged administration of various hormonal suppressive therapies4. The ultrasonographic changes of adenomyosis and endometriosis after the prolonged administration of different hormonal treatments5. The effectiveness of oral contraceptives in improving the endometriosis-related pain and the patients´ quality of life6. The role of Dienogest and other progestogens in the management of endometriosis-related pain7. What to expect from the levonorgestrel-releasing intrauterine device in symptomatic patients with endometriosis?8. The usefulness of less common hormonal treatment modalities in improving the endometriosis-related pain symptoms9. The effectiveness of the gonadotropin-releasing hormone analogues in the treatment of endometriosis-associated pain10. The effectiveness of oral contraceptives in managing the symptoms of adenomyosis11. The role of levonorgestrel-releasing intrauterine device in the management of adenomyosis-related symptoms12. The effectiveness of the gonadotropin-releasing analogues in managing adenomyosis and its related symptoms13. Can the hormonal suppressive therapy reduce the risk of the postoperative endometriosis recurrence and endometriosis-associated cancer?14. The influence of different hormonal therapies on the chances of normal conception in subfertile patients with adenomyosis and endometriosis15. The effect of the prolonged precycle administration of gonadotropin-releasing hormone agonists on the IVF-ET outcomes in patients with endometriosis16. The effectiveness of the progestin-primed ovarian stimulation protocol on the IVF-ET outcomes of patients with endometriosis17. The effectiveness of the prolonged administration of Dienogest before ovarian stimulation in improving the IVF-ET outcomes in patients with endometriosis18. How could the prolonged precycle administration of aromatase inhibitors affect the IVF-ET outcomes of patients with endometriosis?19. The role of the prolonged precycle hormonal suppression in patients with adenomyosis undergoing IVF-ET20. The effect of different endometrial preparation protocols on the frozen-thawed embryo transfer cycle outcomes in patients with adenomyosis and endometriosis

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