In this issue of Veterinary Clinics of North America: Equine Practice, guest editor Dr. Joy E. Tomlinson brings her considerable expertise to the topic of The Equine Liver. Recent years have seen multiple advances in the field of equine hepatitis, with the discovery and report of multiple newly recognized clinical conditions and infectious agents. In this issue, top experts cover the breadth of equine liver function and disease, diagnostics, treatments, and prognosis, with specific conditions reviewed in depth.