The Epigenome and Developmental Origins of Health and Disease

Häftad, Engelska, 2015

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Winner of 2016 BMA Medical Award for Basic and Clinical Sciences

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring.

The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring.

It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples.

Informs how everyday choices pregnant women make can impact child development
Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress)
Includes a boxed-in area in each chapter for further references and resources to keep up with the field
Features video interviews with the authors and other key leaders in the field

Produktinformation

Utgivningsdatum2015-10-23
Mått191 x 235 x 25 mm
Vikt1 130 g
FormatHäftad
SpråkEngelska
Antal sidor560
FörlagElsevier Science
ISBN9780128013830

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Cheryl S. Rosenfeld, DVM, PhD, has published extensively on how maternal diet and developmental exposure to endocrine-disrupting compounds affect offspring outcomes. She has written several review articles and book chapters, including the most recent one on animal models of transgenerational epigenetic effects in Transgenerational Epigenetics: Evidence and Debate, published by Elsevier. She also edited and coauthored the book The Epigenome and Developmental Origins of Health and Disease, which won the BMA Medical Award for Basic and Clinical Sciences in 2016.

1. The Developmental Origins of Health and Disease (DOHaD) concept: past, present and future.2. Historical Perspective of Developmental Origins of Health and Disease in Humans3. DOHaD and the Periconceptional Period, a Critical Window in Time4. Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origins of Health and Diseases Effects5. Fetal Neuro-Hormonal Programming and Endocrine Disruption6. Parental nutrition and developmental origins of health and disease7. Maternal prenatal stress and the developmental origins of mental health: the role of epigenetics8. Epigenetics in the Developmental Origin of Cardiovascular Disorders9. Developmental Effects of Endocrine-Disrupting Chemicals in the Ovary and on Female Fertility10. Developmental and Epigenetic Origins of Male Reproductive Pathologies11. Developmental Origins of Childhood Asthma and Allergic Conditions – is there evidence of epigenetic regulation?12. Immune Disorders, Epigenetics, and the Developmental Origins of Health and Disease13. Neurobehavioral Disorders and DOHaD14. Metabolic Disorders and DOHaD15. The developmental origins of renal dysfunction16. Cancer and DOHaD- Epigenetic reprogramming as a mediator17. Epigenetic regulation of gastrointestinal epithelial barrier and developmental origin of health and disease18. How the Father might Epigenetically Program the Risk for Developmental Origins of Health and Disease Effects in his Offspring19. Linkage Between in Utero Environmental Changes and Preterm Birth20. Sexual Dimorphism and DOHaD Through the Lens of Epigenetics21. Transgenerational Epigenetic Inheritance: Past Exposures, Future Diseases22. The Placenta and DOHaD23. The Moral and Legal Relevance of DOHaD Effects for Pregnant Mothers24. Introduction to Moms in Motion (MIM) Chapter25. Reversing Harmful DOHaD Effects26. Informational Resources for Developmental Origins of Health and Disease Research