The Design and Development of Novel Drugs and Vaccines

Principles and Protocols

Häftad, Engelska, 2021

Av Tarun Kumar Bhatt, Surendra Nimesh, India) Bhatt, Tarun Kumar (Assistant Professor, Department of Biotechnology, Central University of Rajasthan, India) Nimesh, Surendra (UGC Assistant Professor, Central University of Rajasthan, Rajasthan

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The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.

Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume
Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs
Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies
Reviews the most current, cutting-edge research available on vaccine and drug design and development

Produktinformation

Utgivningsdatum2021-01-22
Mått152 x 229 x 22 mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor308
FörlagElsevier Science
ISBN9780128214718

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Tillverkningsindustri inom Ekonomi och ledarskap
Farmakologi inom Medicin

Tarun Kumar Bhatt is an Assistant Professor in the Department of Biotechnology, at the Central University of Rajasthan, India. He received his PhD from the International Centre for Genetic Engineering and Biotechnology, New Delhi and gained post-doctoral experience at the Scripps Research Institute in San Diego, California. He has published over 25 articles and has extensive experience researching drug and vaccine development. Surendra Nimesh, UGC Assistant Professor at Central University of Rajasthan, Rajasthan, India. Surendra received his M.S. in Biomedical Science from the Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi. He completed his PhD. In Nanotechnology at the Institute of Genomics and Integrative Biology (CSIR), Delhi. After completing his postdoctoral studies at the Ecole Polyetchnique of Montreal, Surendra joined the Clinical Research Institute of Montreal (IRCM), Canada as Postdoctoral Fellow. After completing his commitment at IRCM, he joined McGill University for short time. He also worked as NSERC visiting fellow at Health Canada, Canada. His research interests include nanoparticles-mediated gene, siRNA and drug delivery.

1. Introduction of structural bioinformatics with respect to drug discovery2. Target identification and validation3. Retrieval of compounds4. Lead identification and optimization5. Molecular dynamics simulations6. An overview of vaccine design7. Key steps in the selection of vaccine targets8. Epitope prediction and selection of linkers and adjuvant9. Design of vaccine constructs10. In-silico validation through protein-protein docking11. Molecular cloning12. Protein expression13. Protein purification and desalting14. Biological assay15. Biophysical methods16. Outline of animal study for lead/ vaccine testing17. Evaluation of immunogenicity of vaccine candidate18. In-vitro evaluation of lead molecule19. Medical physiological parameter for lead/vaccine testing20. Brief introduction of clinical research and trials21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance22. Introduction of Intellectual property rights

"I have read other books on clinical research, but none with the level of detail and particular focus on drug design (the computational drug design sections) that this one has. This book is very detailed-oriented from that standpoint, and it can certainly serve as a useful tool for those developing vaccines." --© Doody’s Review Service, 2021, Patrick J Scoble, PharmD(PJS Pharma Consulting LLC), reviewer, expert opinion