The Complement FactsBook

Scott Barnum received his B.S. in Biology (cum laude) from Loyola University in Maryland and his Ph.D. from the University of Alabama at Birmingham where he worked on the biosynthesis of factor D for his thesis studies. He then pursued postdoctoral studies on the genomic organization of several complement genes in the Department of Immunology at the Scripps Research Institute. He returned to UAB as a member of the faculty in the Department of Microbiology and holds secondary appointments in the Department of Neurology and the Division of Clinical Immunology and Rheumatology. Since returning to UAB, Dr. Barnum’s research has focused primarily on the role of complement in the central nervous system. Through a combination of in vitro and in vivo studies, his lab demonstrated that glia cells and neurons produce a variety of complement proteins and receptors. Subsequently, the lab identified the role of complement in numerous animal models of human disease including, traumatic brain injury, multiple sclerosis, bacterial meningitis, stroke, and cerebral malaria. In addition to numerous teaching awards, he produced the first high quality animated videos for teaching complement activation and biological functions. Dr. Barnum is currently working on the development of complement diagnostics for use in a variety of infectious disease and autoimmune indications. Theresa Schein received her B.S. in Biology (cum laude) from the University of South Carolina, Aiken where she studied HIV and molecular cloning. Dr. Schein then attended the University of Alabama at Birmingham where she earned her Ph.D. on the role of complement in the development and progression of cerebral malaria. Publishing numerous manuscripts on the role of complement components in experimental cerebral malaria, her studies were seminal in establishing the therapeutic potential of inhibiting the complement terminal pathway in this infectious disease. Upon graduation, she received the Dean’s Outstanding Student Award, among others. She then pursued a short postdoctoral study on the role of the terminal complement pathway in amyotrophic lateral sclerosis at UAB, before transitioning to an entrepreneurial role in a small startup out of St. Louis. While her collaborative efforts have spanned her complement research from infectious to autoimmune disease as demonstrated by her publishing record, Dr. Ramos is currently working on the development of complement centric diagnostics for use in bacterial meningitis.

• 1. Introduction2. The Complement ProteinsC1q and the CollectinsSerine proteasesC3 FamilyTerminal Pathway ComponentsRegulations of Complement Activation (RCA)Cell Surface ReceptorsMiscellaneous Complement Components