The Bipolar Book

Aysegül Yildiz, MDProfessor of PsychiatryDokuz Eylül UniversityIzmir, Turkey; Pedro Ruiz, MDClinical Professor of Psychiatry and Behavioral SciencesUniversity of Texas Medical School at HoustonHouston, TX, USA; Charles B. Nemeroff, MD, PhDLeonard M. Miller Professor & ChairmanDepartment of PsychiatryUniversity of Miami - Miller School of MedicineMiami, FL, USA

• Section I: Clinical PresentationChapter 1. From the Era of Aretaeus to the Millennium: History of Bipolar Disorder Over 2000 YearsChapter 2. Update on Epidemiology, Risk Factors and Correlates of Bipolar Spectrum DisorderChapter 3. Clinical Presentation & DSM-based Diagnostic AssessmentChapter 4. Differential Diagnosis & Bipolar Spectrum DisordersChapter 5. Diagnosing Bipolar Disorder in Children and AdolescentsChapter 6. Effect of Public Awareness & Stigmatization on Accurate & Timely Diagnosis of Bipolar DisorderSection II: Insights on Pathophysiology & Future Treatments Part I: Molecular BiologyChapter 7. Oxidative Damage & Its Treatment ImpactChapter 8. The Role of Signal Transduction Systems in the Pathophysiology and Treatment of Bipolar DisorderChapter 9. Cellular Resilience and Neurodegeneration and Their Impact on the Treatment of Bipolar DisorderChapter 10. Immune Mechanisms and Inflammation & Their Treatment ImpactChapter 11. Circadian Rhythms and Sleep & Its Treatment ImpactChapter 12. HPA & HPT Axis & Their Treatment ImpactChapter 13. Translating Bio-markers and Bio-molecular Treatments to Clinical Practice: Assessment of Hypothesis Driven Clinical Trial DataPart II: GeneticChapter 14. Bipolar Family & Bipolar Offspring Studies: Any Clues for Prevention or Early InterventionChapter 15. The Emerging Genetics of Bipolar DisorderPart III: CognitionChapter 16: Cognitive Impairments and Everyday Disability in Bipolar IllnessPart IV: NeuroimagingChapter 17. Structural & Functional Magnetic Resonance Imaging Findings & Their Treatment ImpactChapter 18. Magnetic Resonance Spectroscopy Findings & Their Treatment ImpactChapter 19. PET Scan Findings & Their Treatment ImpactPart V: Postmortem studies Chapter 20. Postmortem Findings in Bipolar Disorder & Their Treatment ImpactSection III: Current TreatmentsPart I: Pharmacological TreatmentsChapter 21. Treatment of Mania & Mixed StatesChapter 22. Pharmacological Treatment of Acute Bipolar DepressionChapter 23. Maintenance Treatments in Bipolar DisorderChapter 24. Importance of Early Intervention in Bipolar DisorderChapter 25. Alternative and Complementary TreatmentsPart II: Somatic Non-Pharmacological Treatments Chapter 26. ECT and Bipolar Disorder Chapter 27. Neuromodulative Treatments for Bipolar Disorder: Repetitive Transcranial Magnetic Stimulation, Vagus Nerve Stimulation and Deep Brain StimulationPart III: Adverse treatment effectsChapter 28. Management of Metabolic and Endocrinological EffectsChapter 29. Neurological, Cognitive and Neuroprotective Effects of Treatments in Bipolar DisorderChapter 30. Treatment Induced Mood Instability-TEAs and Cycle AccelerationPart IV: PsychotherapyChapter 31. Cognitive Behavioral Therapy and Psychoeducation Chapter 32. Family Focused Therapy, Interpersonal and Social Rhythm Therapy & Dialectical Behavioral TherapyPart V: ComorbidityChapter 33. Management of Comorbid Axis-I Psychiatric DisordersChapter 34. Management of Cyclothymia and Comorbid Axis-II Psychiatric DisordersChapter 35. Management of Comorbid Substance or Alcohol AbuseChapter 36. Management of Comorbid Medical ProblemsPart VI: SuicidalityChapter 37. Clinical Management of Suicide RiskPart VII: Pregnancy & LactationChapter 38. Management of Bipolar Disorder During Pregnancy and LactationPart VIII: Children & AdolescentsChapter 39. Management of Bipolar Disorder in Children and AdolescentsPart IX: ElderlyChapter 40. Bipolar Disorder in the ElderlySection IV: Future ResearchChapter 41. Placebo Response in Clinical Trials for Bipolar Disorder: Potential Causes, Potential SolutionsChapter 42. Strategies for Improving Randomized Trial Evidence in Treatment of Bipolar DisorderChapter 43. Challenges in Designing Reliable and Feasible Treatment Trials for Bipolar DisorderChapter 44. Sequential Multiple Assignment Randomized TrialsChapter 45. Traditional and Novel Research Synthesis Approaches to Support Evidence-based Treatment Decisions