Textbook of Practical Physiology has been greatly appreciated by students, residents, members of faculty, laboratory technical officers, and practicing physicians in India and abroad for about two and a half decades. The popularity of this book can be attributed to the fact that it fulfils all the requirements of students and teachers—imparting detailed knowledge of techniques, helping to develop practical skills, and guiding their application in physiology and medicine. With the introduction of the revised NMC CBME – 2024 curriculum, there is a clear shift towards an evidence-based, objective-oriented, clinically-focussed, and skill-based, integrated curriculum.