Textbook of Nephro-Endocrinology

Nyhet

Inbunden, Engelska, 2026

AvAjay K. Singh,Gordon H. Williams,Ajay K Singh,Gordon H Williams

2 459 kr

Kommande

Textbook of Nephro-Endocrinology, Third Edition remains the definitive translational reference in the field of nephroendocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. This new edition includes updates on the pathophysiology of inflammation, iron metabolism and erythropoiesis, mineralocorticoid receptor antagonists, the treatment of pre-eclampsia, and HIF-PHIs. The book offers researchers and clinicians expert analyses of nephroendocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism.

Since the publication of the 2nd edition in 2009, many updates and new findings have emerged.

Presents emerging data on the role of metabolic acidosis in the progression of CKD and novel agents to treat pre-eclampsia, including proton pump inhibitors, metformin, micronutrients, and biologics
Covers the role of metabolic acidosis in kidney progression, metabolic acidosis, and chronic kidney disease
Offers clear, translational presentations by top endocrinologists and nephrologists in each specific hormone or functional/systems field

Produktinformation

Utgivningsdatum2026-06-01
Mått216 x 276 x undefined mm
Vikt450 g
FormatInbunden
SpråkEngelska
Antal sidor570
Upplaga3
FörlagElsevier Science
ISBN9780443217517

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Dr. Singh has led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propyl hydroxylase inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. He currently leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital, and in this capacity leads several HMS CME courses. He is the author of over 160 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University. Dr. Gordon H. Williams is an endocrinologist in Boston, Massachusetts and is affiliated with Brigham and Women's Hospital. He received his medical degree from Harvard Medical School and has been in practice for more than 30 years. He has published ~300 papers, is a well-respected and well-known expert, speaker and leader in the field of endocrinology.

1. Erythropoietin: A Historical Overview of Physiology, Molecular Biology, and Gene Regulation2. Erythropoiesis: The Roles of Erythropoietin and Iron3. Extra-Hematopoietic Action of Erythropoietin4. Development of Recombinant Erythropoietin and Erythropoietin Analogs5. Erythropoietin. Anemia and Kidney Disease6. Novel Erythropiesis Stimulating Agents7. Vitamin D and the Kidney: Introduction and Historical Perspective8. Vitamin D: Molecular Biology and Gene Regulation9. Molecular Biology of Parathyroid Hormone *& Calcium Sensing?10. Endocrine Regulation of Phosphate Homeostatis11. Clinical Syndromes of Vitamin D and Phosphate Dysregulation12. The Renin-Angiotensin System; History and Introduction13. Molecular Biology of Renin and Regulation of its Gene14. Physiology and Regulation of the Renin-Angiotensin-Aldosterone System15. The Renin-Angiotensin System and the Kidney16. The Renin-Angiotensin System and the Heart17. Renin-Angiotensin Blockade: Therapeutic Agents (Hypertension)18. Vasopressin in the Kidney: Historical Asptects19. Molecular Biology and Gene Regulation of Vasopressin20. Vasopressin Antagonists in Physiology and Disease21. Diabetes Insipidus and SIADH22. ANP, BNP, and CNP: Physiology and Pharmacology of the Cardiorenal Axis23. Aldosterone: History and Introduction24. Aldosterone Mechanism of action: genomic and non-genomic25. Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation26. Aldosterone and Its Cardiovascular Effects27. Novel mineralocorticoid Receptor Antagonists28. Regulation of Aldosterone Production29. Insulin Resistance and Diabetes in Chronic Renal Disease30. Growth Hormone31. Sexual Dysfunction in Men and Women with Chronic Kidney Disease32. Thyroid Status in Chronic Renal Failure Patients - a Non-Thyroidal Illness Syndrome33. Metabolic Acidosis of Chronic Kidney Disease - its role in progression34. Pregnancy and the Kidney35. Novel agents for the treatment of Pre-eclampsia

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