Textbook of Influenza

Edited by:Robert G. Webster, Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, MemphisArnold S. Monto, School of Public Health, University of Michigan, Ann Arbor, MichiganThomas J. Braciale, University of Virginia School of Medicine, Charlottesville, VirginiaRobert A. Lamb, Howard Hughes Medical Institute, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois

• List of contributors, ixForeword to the second edition, xivPreface to the second edition, xviAcknowledgments, xviiPART 1 Influenza: Perspective1 Human influenza: One health, one world, 3Daniel B. Jernigan and Nancy J. Cox2 Influenza pandemics: History and lessons learned, 20Arnold S. Monto and Robert G. WebsterPART 2 Structure and replication3 Structure, disassembly, assembly, and budding of influenza viruses, 37Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, Gwendolyn Lee, and Z. Hong Zhou4 The virus genome and its replication, 57Robert M. Krug and Ervin Fodor5 Influenza glycoproteins: Hemagglutinin and neuraminidase, 67Rupert J. Russell, Steven J. Gamblin, and John J. Skehel6 Proton channels of influenza A and B viruses, 101Chunlong Ma, Lawrence H. Pinto, and Robert A. Lamb7 The NS1 protein: A master regulator of host and viral functions, 114Robert M. Krug and Adolfo García-Sastre8 Structure and function of the influenza virus replication machinery and PB1-F2, 133Andrew Mehle and Jonathan A McCullers9 The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation, 146Gabriele Neumann and Yoshihiro Kawaoka10 Pathogenesis, 157Hans Dieter Klenk, Wolfgang Garten, and Mikhail MatrosovichPART 3 Evolution and ecology of influenza viruses11 Ecology and evolution of influenza viruses in wild and domestic birds, 175Ron A.M. Fouchier and Yi Guan12 Influenza in swine, 190Richard Webby and Juergen Richt13 Equine/Canine/Feline/Seal influenza, 203Thomas M. Chambers, Edward J. Dubovi, and Ruben O. Donis14 Emergence and Evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains, 218Taia T. Wang and Peter PalesePART 4 Epidemiology and surveillance15 Influenza surveillance and laboratory diagnosis, 231Maria Zambon16 Epidemiology of influenza, 250Marc-Alain Widdowson and Arnold S. MontoPART 5 Immunology of influenza17 Innate immunity, 269Akiko Iwasaki and Malik Peiris18 Antibody-mediated immunity, 283Nicole Baumgarth,Michael C. Carroll, and Santiago Gonzalez19 Cell-mediated immunity, 298Stephen J. Turner, Peter C. Doherty, and Anne KelsoPART 6 Vaccines and vaccine development20 Immunogenicity, efficacy of inactivated/live virus seasonal and pandemic vaccines, 313Wendy A. Keitel, Kathleen M. Neuzil, and John Treanor21 New approaches to vaccination, 327Chih-Jen Wei, Damian C. Ekiert, Gary J. Nabel, and Ian A. Wilson22 Control of influenza in animals, 337Ilaria Capua and Dennis J. Alexander23 Influenza vaccine production, 352Klaus StöhrPART 7 Clinical aspects and antivirals24 Human influenza: Pathogenesis, clinical features, and management, 373Frederick G. Hayden and Menno D. de Jong25 Antivirals: Targets and use, 392Michael G. Ison and Alan Hay26 The control of influenza and cost-effectiveness of interventions, 419Carolyn B. Bridges, Samuel K. Peasah, and Martin I. Meltzer27 Applications of quantitative modeling to influenza virus transmission dynamics, antigenic and genetic evolution, and molecular structure, 434Marc Lipsitch and Derek Smith28 Pandemic preparedness and response, 453Jonathan S. Nguyen-Van-Tam and Joseph Bresee29 Influenza: The future, 470Thomas J. BracialePART 8 The outbreak of H7N930 Appendix, 479Thomas J. Bracial