Targeted Cancer Treatment in Silico

Natalia Komarova and Dominik Wodarz are professors at University of California, Irvine.

• Background and Scope of the Book.- Part I Treatment of Cancer with Small Molecule Inhibitors.- An Introduction to Small Molecule Inhibitors and Chronic Myeloid Leukemia.- Basic Dynamics of Chronic Myeloid Leukemia During Imatinib Treatment.- Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation.- Evolutionary Dynamics of Drug Resistant Mutants in Targeted Treatment of CML.- Effect of Cellular Quiescence on the Evolution of Drug Resistance in CML.- Combination Therapies: Short term versus Long term Strategies.- Cross Resistance: Treatment and Modeling.- Mathematical Modeling of Cyclic Cancer Treatments.- Part II Treatment of Cancer with Oncolytic Viruses.- Introduction to Oncolytic Viruses.- Basic Dynamics of Oncolytic Viruses.- Mitotic Virus Transmission and Immune Responses.- Axiomatic Approaches to Oncolytic Virus Modeling.- Spatial Oncolytic Virus Dynamics.- Oncolytic Viruses and the Eradication of Drug-resistant Tumor Cells.

From the reviews: "The intended audience includes advanced undergraduate and graduate students in applied mathematics as well as in the field of biology with a special interest in oncology. It could serve as a guide to scientists and researchers in the field of oncology and therapeutics. ... This is the first in-depth study of mathematical and computational approaches used to understand cancer therapies. The crisp language, well-structured chapters, and precise examples are the highlights of this book." (Parthiv Amin, Doody's Book Reviews, March, 2014)