T Cell Metabolism and Cancer Immunotherapy

T Cell Metabolism and Cancer Immunotherapy investigates the cellular regulation of T-cell immunity and tolerance. Within ten chapters, the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy. Because of the plasticity and potentially unlimited capacity for self-renewal, stem cell-derived T lymphocytes have great potential in the treatment of diseases, including cancer.?Despite great advancement in immunotherapy, such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy.?

• Provides a summary of the current state-of-the-art, creating a valuable foundation for both established researchers and newcomers/students in the field of cancer immunotherapies
• Focuses on the investigation of cellular regulation of T-cell immunity and tolerance
• Defines the precise role and mechanism of T cell metabolism in modulating T cells and T cell-mediated immunity
• Presents insights to develop and optimize strategies for utilizing highly reactive T lymphocytes for cell-based therapies