Edda Klipp (born 1965) studied theoretical biophysics at the Humboldt University Berlin. A member of the Yeast Systems Biology Network, her research interests include mathematical modeling of cellular systems, signal transduction, systems biology, and text mining. Wolfram Liebermeister (born 1972) studied physics in Tubingen and Hamburg and obtained a PhD of theoretical biophysics at the Humboldt University of Berlin. In his works on complex biological systems, he points out functional aspects like variability, information, and optimality. Christoph Wierling (born 1973) studied biology at the University of Munster and recently obtained a PhD degree on the modeling and simulation of biological systems. Axel Kowald (born 1963) holds a PhD in mathematical biology from the National Institute for Medical Research, London. His current research interests focus on the mathematical modeling of processes involved in the biology of aging and systems biology.

• INTRODUCTION TO SYSTEM BIOLOGYIntroductionModeling of Biochemical SystemsStructural Modeling and Analysis of Biochemical NetworksKinetic Models of Biochemical Networks IntroductionData Formats, Simulation Techniques, and Modeling ToolsModel Fitting, Reduction, and CouplingDiscrete, Stochastic, and Spatial ModelsNetwork Structures, Dynamics and FunctionGene Expression ModelsVariability, Robustness, and InformationEvolution and OptimalityModels of Biochemical Systems REFERENCE SECTIONCell Biology Experimental Techniques Mathematical and Physical ConceptsDatabases Software Tools for Modeling

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