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The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis.
Foreword.- Modeling Mycobacterium tuberculosis H37Rv in silico.- Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis.- Probing Gene Regulatory Networks to Decipher Host-Pathogen Interactions.- Metabolism of Mycobacterium tuberculosis.- Protein-protein interaction in the –omics era: Understanding Mycobacterium tuberculosis function.- A systems biology approach for understanding granuloma formation and function in tuberculosis.- Stochastic gene expression in bacterial pathogens: a mechanism for persistence?.- Drug Discovery.- Diagnosis.- Index.