This brief highlights innovative and creative applications of established clinical interventions across different systemic models, with clients of South Asian Indian background, including foundational, contemporary, and empirically based approaches. Chapters illustrate a specific systemic intervention and how it has been adapted and therapeutically applied by each author to a particular South Asian Indian client population (e.g., LGBTQ+ youth, recent immigrant families, interracial couples) and specific presenting problem issue (e.g., SUDs, affective disorders, couple intimacy issues, parenting, partner selection, career, technology, etc.). In addition, chapters provide practical ideas for the application of systemic interventions through service delivery approaches that address the unique needs of this client population. Key areas of coverage include: Specific systemic interventions that have been creatively adapted for clinical application with South Asian Indian clients.Step-by-step process of adapting and utilizing the systemic intervention.Innovative intervention, assessment, and service delivery models.Case examples highlighting the development and application of specific systemic interventions.Recommendations for clinicians to expand and elaborate established systemic models to better address the diverse needs of diverse client populations. Systemic Therapy with South Asian Populations is an essential resource for clinicians, therapists, and practitioners as well as researchers, professors, and graduate students in family studies, clinical psychology, and public health, as well as all interrelated disciplines.