Synthesis and Operability Strategies for Computer-Aided Modular Process Intensification

Efstratios N. Pistikopoulos is a distinguished chemical engineer and academic leader, currently serving as Director of the Texas A&M Energy Institute and holding the Dow Chemical Chair Professorship in the Artie McFerrin Department of Chemical Engineering at Texas A&M University. He holds a PhD in Chemical Engineering from Carnegie Mellon University in the USA. He has been working at Shell Chemicals in Amsterdam. He has served as Professor of Chemical Engineering at Imperial College London, directing the Centre for Process Systems Engineering. His research focuses on process systems engineering, particularly multi-parametric programming, model predictive control, and integrated frameworks for designing, optimizing, and scheduling complex systems with applications in energy, manufacturing, and biomedical engineering. Dr. Pistikopoulos is the lead developer of the PAROC framework and has authored hundreds of publications and several books. Professor Pistikopoulos is a Fellow of the Royal Academy of Engineering, IChemE, and AIChE, and has received numerous honors, including the AIChE Computing in Chemical Engineering Award, the IChemE Sargent Medal, and the Royal Academy of Engineering's MacRobert Award. He also serves as Editor-in-Chief of Computers & Chemical Engineering, underscoring his global leadership in advancing process systems engineering. Dr. Yuhe Tian is Assistant Professor in the Department of Chemical and Biomedical Engineering at West Virginia University. Prior to joining WVU, she received her Ph.D. degree in Chemical Engineering from Texas A&M University (2016-2021). She holds Bachelor’s degrees in Chemical Engineering and Mathematics from Tsinghua University, China (2012-2016). Her research focuses on the development and application of multi-scale systems engineering tools for modular process intensification, sustainable energy systems, advanced control and real-time decision-making.

• 1. Introduction to process intensification2. Towards computer-aided process intensification3. Phenomena-based synthesis for process intensification4. Process synthesis, optimization and intensification5. Process synthesis, intensification and heat integration6. Material selection, process synthesis and intensification7. Operability and control challenges in process intensification 8. Steady-state and dynamic flexibility analysis9. Inherent safety analysis10. Advanced model-based control11. Synthesis and optimization of operable process intensification systems12. Identification of performance limits for olefin metathesis reactive separation process13. Synthesis of ethanol-water extractive separation systems with ionic liquid solvents selection14. Process design and intensification of an industrial dividing wall column for methyl methacrylate separation15. Steady-state synthesis and design of methyl tert-butyl ether production process with safety and operability considerations16. Simultaneous design and control of a methyl tert-butyl ether reactive distillation system17. A framework for synthesis of operable and intensified systems