Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

• 1. Molecular basis of thyroid hormone action.- 2. Tissues specific action of thyroid hormones: insights from knock out animal models.- 3. Learning from nature’s experiments on the thyroid hormone receptor; X-ray structures of RTH mutant ligand-binding domains.- 4. Molecular pathogenesis of resistance to thyroid hormone.- 5. Syndromes of resistance to thyroid hormone: clinical aspects.- 6. Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes.- 7. Lessons learned from TR-? mutant mice.- 8. Towards the rational design of hormone analogs which complement receptor mutations.- 9. Multi-factorial regulation of in vivo action of TR? mutants. Lessons learned from RTH mice with a targeted mutation in the TR? gene.- 10. The effect of vitamin A, retinoids and retinoid receptors on the hypothalamic-pituitary-thyroid axis.- 11. Pituitary resistance to thyroxine action due to a defect in the type 2 deiodinase.- 12. Different forms of resistance to thyrotropin (TSH) action.

"Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis is a tour-de force by expert authors in the field of thyroid hormone action. Using clinical syndromes of thyroid hormone and TSH resistance, they explore the fundamental mechanisms for thyroid hormone structure-function defects and translate these fascinating molecular observations into an understanding of the pathogenesis of human disease. Endocrinologists, internists, pediatricians and students of the thyroid axis and hormone action will enjoy the depth and breadth of information which has been assembled by the Editor to provide a truly unique cutting edge state of the art." (Shlomo Melmed, M.D., Series Editor, "Endocrine Updates)