This book constitutes the refereed proceedings of the Second International Conference on Sustainable Development through Machine Learning, AI and IoT, ICSD 2024, held in Virtual Event, during April 27–28, 2024.The 38 full papers presented here were carefully reviewed and selected from 167 submissions. These papers have been categorized into the following sections: This volume encompassing a diverse array of topics at the intersection of cutting-edge technologies and practical applications. Each chapter delves into innovative approaches and solutions, providing valuable insights into contemporary challenges and opportunities in various domains. Here, we explore the realms of blockchain, data science, machine learning, artificial intelligence, and more, offering in-depth analyses and practical implementations.