Suicide Gene Therapy

• to the Background, Principles, and State of the Art in Suicide Gene Therapy.- to Vectors for Suicide Gene Therapy.- Construction of VNP20009.- Nonreplicating DNA Viral Vectors for Suicide Gene Therapy.- Replication-Selective Oncolytic Adenoviruses.- Retroviral Vectors for Suicide Gene Therapy.- Nonviral Liposomes.- Peptide- and Polymer-Based Gene Delivery Vehicles.- Design of Prodrugs for Suicide Gene Therapy.- Cytochrome P450-Based Gene Therapies for Cancer.- Tumor Sensitization to Purine Analogs by E. coli PNP.- Enzyme-Prodrug Systems.- Enzyme-Prodrug Systems.- Methods to Improve Efficacy in Suicide Gene Therapy Approaches.- Extracellular ?-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy.- Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis.- Combination Suicide Gene Therapy.- Immune Response to Suicide Gene Therapy.- Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus.- Radiation-Activated Antitumor Vectors.- In Vitro and In Vivo Models for Evaluation of GDEPT.- Suicide Gene Therapy in Liver Tumors.- Clinical Trials With GDEPT.- The Nitroreductase/CB1954 Enzyme-Prodrug System.- Side Effects of Suicide Gene Therapy.- Antibody-Directed Enzyme-Prodrug Therapy.- Bioreductive Prodrugs for Cancer Therapy.

"This is a good book for those working in the area of suicide gene therapy that can serve both as a reference to senior investigators as well as a primer to new lab members and researchers outside the field who are trying to get a flavor of the state of the field."-Doody's Health Sciences Book Review Journal "...an extensive review of the theoretical background of suicide gene therapy that covers all major aspects..." - ChemBioChem "Authoritative and up-to-date...provides the experimental means to advance its future development and therapeutic applications." - Anticancer Research