This book gathers peer-reviewed contributions presented at the 6th International Conference on Structural and Physical Aspects of Construction Engineering (SPACE), held in Štrbské Pleso, High Tatras, Slovakia, on October 15–17, 2025. Aiming at bringing together researchers and engineers devoting to structural and physical problems in different areas of engineering applications, it covers topics such as static and dynamic analysis of structures, seismic and stability problems of structures, experimental analysis and diagnostics of structures, resistance, durability and reliability of structures, composite materials and structures, failure, creation and growth of cracks, damages and reconstructions of structures, structural, shape and material optimization of structures, fluid mechanics and thermomechanics, transportation structures, and environmental engineering. The contributions, which were selected through a rigorous international peer-review process, share exciting ideas that will spur novel research directions and foster new multidisciplinary collaborations.