Del 0 - Handbook of Experimental Pharmacology

Stress Proteins

Inbunden, Engelska, 1998

AvH. Abe,David Latchman,David S. Latchman

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The stress proteins or heat shock proteins were originally identified on the basis of their enhanced synthesis following stress. It is now clear, however, that they also play a key role in stressed cells and in specific human diseases. This book provides a comprehensive account of these proteins, emphasizing the functions of the different stress proteins in unstressed and stressed cells of different types, their regulation by stressful and non-stressful stimuli and their roles in a range of human diseases.

Produktinformation

Utgivningsdatum1998-11-26
Mått155 x 235 x 32 mm
Vikt916 g
FormatInbunden
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor422
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540650171

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1 Stress Proteins: An Overview.- 2 The Hsp90 Chaperone Family.- 3 Heat Shock Protein 70.- 4 Mitochondrial Molecular Chaperones hsp60 and mhsp70: Are Their Roles Restricted to Mitochondria?.- 5 Role of Hsp27 and Related Proteins.- 6 Ubiquitin and the Stress Response.- 7 Regulation of Heat Shock Genes by Cytokines.- 8 Regulation of Heat Shock Genes by Ischemia.- 9 Regulation of Heat Shock Transcription Factors by Hypoxia or Ischemia/Reperfusion in the Heart and Brain.- 10 Autoregulation of the Heat Shock Response.- 11 The Cellular Stress Gene Response in Brain.- 12 Heat Stress Proteins and Their Relationship to Myocardial Protection.- 13 Heat Shock Proteins in Inflammation and Immunity.- 14 Heat Shock Proteins in Embryonic Development.- 15 Heat Shock Proteins in Rheumatoid Arthritis.- 16 Heat Shock Protein 60 and Type I Diabetes.- 17 Heat Shock Proteins and Multiple Sclerosis.- 18 Heat Shock Proteins in Atherosclerosis.- 19 Heat Shock Protein-Peptide Interaction: Basis for a New Generation of Vaccines Against Cancers and Intracellular Infections.