Stem Cell Therapeutics for Cancer

Khalid Shah, MS, PhD is an Associate Professor of Neurology and Radiology at Massachusetts General Hospital Harvard Medical School, where he also directs the Molecular Neurotherapy and Imaging Lab and the Stem Cell Imaging and Therapeutics Program. In addition to Dr. Shah's teaching and directorial activities, he is also a member of the editorial board for Nature Medicine, PNAS, Journal of Clinical Investigation, Stem Cells and Nature Neuroscience.

• Contributors viiPreface xiSection 1 Introduction 11 Stem Cell Sources and Their Potential for Cancer Therapeutics 3Khalid ShahSection 2 Migration and Fate of Stem Cells 112 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration 13Moneeb Ehtesham, Elliot Min, and Rebecca Kasl3 Tumor Tropism of Mesenchymal Stem Cells 21Paula Y. P. Lam and Ivy A.W. HoSection 3 Stem Cell Therapy in Brain Cancer 394 Stem Cell-Mediated Trail Therapy for Highly Aggressive Brain Tumors 41Khalid Shah5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors 57Cestmir Altaner6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy 73Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S. Rao7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors 87Navid Redjal and Khalid Shah8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell-Based Oncolytic Virotherapy 103Manuel Ramírez and Javier García-CastroSection 4 Stem Cell Therapy in Other Cancer Types 1119 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer 113Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, and Masaaki Tamura10 Mesenchymal Stromal Cells as Effective Tumor Antigen-Presenting Cells in Cancer Therapeutics 127Raphaëlle Romieu-Mourez and Jacques Galipeau11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment 145Róisín Dwyer12 Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy 159Emily Keung, Peter J. Nelson, and Claudius Conrad13 Mesenchymal Stem Cells in Prostate Cancer: Clinical Opportunities 171Diptiman Chanda and Selvarangan Ponnazhagan14 Primed Mesenchymal Stromal Cells for Cancer Therapy 187Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini, and Giulio AlessandriSection 5 Combinatorial Stem Cell Therapies 20315 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy 205Maarten C. J. Anderegg and Maarten F. Corsten16 Stem Cell-Based Combination Therapies for Cancer: Systemic Delivery of a PI3K/mTOR Inhibitor (PI-103) and Stem Cell-Mediated Delivery of TRAIL in Brain Tumors 219Tugba Bagci-Onder17 The Efficacy of Clinically Approved Agents with Stem Cell-Delivered Therapeutics for Cancer Therapy 235Hiroaki Wakimoto and Khalid ShahSection 6 Tracking Stem Cells and Stem Cell-Based Therapeutics 24518 Imaging Migration and Fate of Stem Cells in Experimental Models of Cancer 247Deepak Bhere and Khalid Shah19 Multifunctional Molecules for Interrogating Stem Cell-Based Therapeutics 257Shawn Hingtgen20 Tracking Cancer-Targeted MSC with PET Imaging 273Véronique Roelants and Jean-Louis VanoverscheldeIndex 289Color plate is located between pages 244 and 245.