Stellate Cells in Health and Disease

Inbunden, Engelska, 2015

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Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs.

The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer.

Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.

Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy.
Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology.
Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Produktinformation

Utgivningsdatum2015-04-14
Mått191 x 235 x 22 mm
Vikt790 g
FormatInbunden
SpråkEngelska
Antal sidor336
FörlagElsevier Science
ISBN9780128001349

Tillhör följande kategorier

Neurologi och klinisk neurofysiologi inom Medicin
Fysiologi inom Medicin

Dr. Chandrashekhar Gandhi is a professor within the department of Surgery at the University of Cincinnati. His laboratory focuses on the mechanisms of intercellular communications that regulate the structure and function of the liver in physiology and pathology. Present research elucidates specific molecular and biochemical mechanisms underlying effects of stellate cells. Dr. Gandhi is a member of the American Association for Advancement of Science, The New York Academy of Sciences, American Society for Biochemistry and Molecular Biology, International Liver Transplantation Society, American Association for the Study of Liver Diseases, and the American Society for Investigative Pathology. He has contributed over 70 published research articles and owns the patent for “Diagnostic and Therapeutic Uses of Augmenter of Liver Regeneration (ALR) in Inflammatory Conditions (PCT/US2008/075440).

Chapter 1. History and Early WorkChapter 2. Stellate Cell Culture ModelsChapter 3. Hepatic Fibrosis: A Global Clinical ProblemChapter 4. Stellate Cells and Hepatic FibrosisChapter 5. Cytokin Production and Signaling in Stellate CellsChapter 6. Stellate Cells, Portal Myofibroblasts and Epithelial-Mesenchymal TransitionChapter 7. Matrix Melalloproteinases and their InhibitorsChapter 8. Matrix Melalloproteinases and their InhibitorsChapter 9. Stellate Cells and Liver CancerChapter 10. Morphogens and hepatic stellate cell fate regulationChapter 11. Stellate Cells in alcoholic SteatohepatitisChapter 12. Stellate Cells as target for Reversal of Fibrosis/CirrhosisChapter 13. Interactions of Stellate Cells with other Nonparenchymal CellsChapter 14. Stellate Cells in Regulation of Hepatocyte Survival and FunctionsChapter 15. Stellate Cells in hepatic ImmunobiologyChapter 16. Stellate Cell Depletion ModelsChapter 17. Stellate Cells in Nonhepatic Organs