Statistical Analysis of Failure Time Data

JOHN D. KALBFLEISCH, PhD, is Professor of Biostatistics at the University of Michigan in Ann Arbor and the University of Waterloo in Ontario, Canada. ROSS L. PRENTICE, PhD, is Professor of Biostatistics at the Fred Hutchinson Cancer Research Center and the University of Washington in Seattle.

• Preface. 1. Introduction. 1.1 Failure Time Data. 1.2 Failure Time Distributions. 1.3 Time Origins, Censoring, and Truncation. 1.4 Estimation of the Survivor Function. 1.5 Comparison of Survival Curves. 1.6 Generalizations to Accommodate Delayed Entry. 1.7 Counting Process Notation. Bibliographic Notes. Exercises and Complements. 2. Failure Time Models. 2.1 Introduction. 2.2 Some Continuous Parametric Failure Time Models. 2.3 Regression Models. 2.4 Discrete Failure Time Models. Bibliographic Notes. Exercises and Complements. 3. Inference in Parametric Models and Related Topics. 3.1 Introduction. 3.2 Censoring Mechanisms. 3.3 Censored Samples from an Exponential Distribution. 3.4 Large-Sample Likelihood Theory. 3.5 Exponential Regression. 3.6 Estimation in Log-Linear Regression Models. 3.7 Illustrations in More Complex Data Sets. 3.8 Discrimination Among Parametric Models. 3.9 Inference with Interval Censoring. 3.10 Discussion. Bibliographic Notes. Exercises and Complements. 4. Relative Risk (Cox) Regression Models. 4.1 Introduction. 4.2 Estimation of . 4.3 Estimation of the Baseline Hazard or Survivor Function. 4.4 Inclusion of Strata. 4.5 Illustrations. 4.6 Counting Process Formulas. 4.7 Related Topics on the Cox Model. 4.8 Sampling from Discrete Models. Bibliographic Notes. Exercises and Complements. 5. Counting Processes and Asymptotic Theory. 5.1 Introduction. 5.2 Counting Processes and Intensity Functions. 5.3 Martingales. 5.4 Vector-Valued Martingales. 5.5 Martingale Central Limit Theorem. 5.6 Asymptotics Associated with Chapter 1. 5.7 Asymptotic Results for the Cox Model. 5.8 Asymptotic Results for Parametric Models. 5.9 Efficiency of the Cox Model Estimator. 5.10 Partial Likelihood Filtration. Bibliographic Notes. Exercises and Complements. 6. Likelihood Construction and Further Results. 6.1 Introduction. 6.2 Likelihood Construction in Parametric Models. 6.3 Time-Dependent Covariates and Further Remarks on Likelihood Construction. 6.4 Time Dependence in the Relative Risk Model. 6.5 Nonnested Conditioning Events. 6.6 Residuals and Model Checking for the Cox Model. Bibliographic Notes. Exercises and Complements. 7. Rank Regression and the Accelerated Failure Time Model. 7.1 Introduction. 7.2 Linear Rank Tests. 7.3 Development and Properties of Linear Rank Tests. 7.4 Estimation in the Accelerated Failure Time Model. 7.5 Some Related Regression Models. Bibliographic Notes. Exercises and Complements. 8. Competing Risks and Multistate Models. 8.1 Introduction. 8.2 Competing Risks. 8.3 Life-History Processes. Bibliographic Notes. Exercises and Complements. 9. Modeling and Analysis of Recurrent Event Data. 9.1 Introduction. 9.2 Intensity Processes for Recurrent Events. 9.3 Overall Intensity Process Modeling and Estimation. 9.4 Mean Process Modeling and Estimation. 9.5 Conditioning on Aspects of the Counting Process History. Bibliographic Notes. Exercises and Complements. 10. Analysis of Correlated Failure Time Data. 10.1 Introduction. 10.2 Regression Models for Correlated Failure Time Data. 10.3 Representation and Estimation of the Bivariate Survivor Function. 10.4 Pairwise Dependency Estimation. 10.5 Illustration: Australian Twin Data. 10.6 Approaches to Nonparametric Estimation of the Bivariate Survivor Function. 10.7 Survivor Function Estimation in Higher Dimensions. Bibliographic Notes. Exercises and Complements. 11. Additional Failure Time Data Topics. 11.1 Introduction. 11.2 Stratified Bivariate Failure Time Analysis. 11.3 Fixed Study Period Survival Studies. 11.4 Cohort Sampling and Case-Control Studies. 11.5 Missing Covariate Data. 11.6 Mismeasured Covariate Data. 11.7 Sequential Testing with Failure Time Endpoints. 11.8 Bayesian Analysis of the Proportional Hazards Model. 11.9 Some Analyses of a Particular Data Set. Bibliographic Notes. Exercises and Complements. Glossary of Notation. Appendix A: Some Sets of Data. Appendix B: Supporting Technical Material. Bibliography. Author Index. Subject Index.

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