• and historical overview.- Phytochemistry.- St. John’s Wort and its active principles in depression and anxiety — A critical analysis of receptor binding studies.- Effects on transmitter uptake and their cellular and molecular basis.- Modulation of neurotransmitter release and metabolism.- Efficacy in behavioural models of antidepressant activity.- Comparative preclinical antidepressant activity of isolated constituents.- Hyperforin and efficacy in animal models for anxiety and cognition.- Pharmacokinetics and biopharmaceuticals.- Clinical efficacy in depression.- Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression.- Side effects and drug interactions.- Endocrinology of St. John’s Wort extract.

From the reviews: ...this book presents an excellent account of experimental as well as clinical research that has been done on St. John's wort. Not only have the authors been successful in presenting up-to-date information on many important topics but they have succesfully discussed the pros and cons of many conclusions. (Journal of Medicinal Chemistry) "The book under discussion here comprises 13 chapters providing comprehensive information on all relevant aspects regarding both the medical and the pharmaceutical appraisal of this herbal antidepressant. ... represents an excellent compilation of the results of research done on St. John's wort. All important aspects are taken into consideration with constant quality. The text of the book is of reasonable comprehensibility. The figures and tables provided are useful and well organized. ... I recommend this book to anybody interested in this topic." (Eckart Eich, Economic Botany, Vol. 63 (4), 2009)