Squamous cell Carcinoma

Professor Saman Warnakulasuriya OBE has extensive experience in conducting international collaborative research projects including clinical trials and a strong expertise of managing Head and Neck cancers.  He has championed ways to relocate his clinical follow up studies and experimental data from the laboratory into the real-world. His contributions as the Director of World Health Organization Collaborating Centre for Oral Cancer has over a decade catalysed a global collaborative effort to improve adherence to high standards of clinical care in his speciality around the world.His experimental studies have reported on clinical adjunctive aids and novel ways of stratifying patients at high risk and reported on several biomarkers for the prediction of risk of malignant transformation from precancer to cancer. He has published over 260 peer reviewed papers mostly on oral cancer and premalignancy and several systematic reviews and book chapters. He is the recipient of several key scientific awards as a distinguished scientist and for his distinguished service to King’s College London for over 25 years.

• Preface.- Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck.- Cancer Stem Cells - Biopathology with reference to Head & Neck Cancers.- Hypoxia in head and neck cancer.- Genetic aberrations and molecular pathways in head and neck cancer.- p53 in Head and Neck Squamous Cell Carcinoma.- Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck.- Targeting the mTOR signaling circuitry in head and neck cancer.- Survivin as a Therapeutic Target in Squamous Cell Carcinoma.- MicroRNA:  utility as biomarkers and therapeutic targets in squamous cell carcinoma.- Envoi – An appraisal of Targeted Therapies for Head and Neck Cancer.- Index.