Sperm Chromatin for the Clinician

Armand Zini, MD, Department of Surgery, Division of Urology, McGill University, St. Mary's Hospital Center, Montreal, QC, Canada Ashok Agarwal, PhD, HCLD (ABB), Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA

• Part I: Biological Determinants of Sperm Chromatin Damage.- Sperm Chromatin: An Overview.- Spermatogenesis: An Overview.- Role of Oxidative Stress in the Etiology of Sperm DNA Damage.- Abortive Apoptosis and Sperm Chromatic Damage.- Spermiogenesis in Sperm Genetic Integrity.- Part II: Clinical Aspects of Sperm Chromatin Damage.- Male Subfertility and Sperm Chromatin Damage.- Aging and Sperm DNA.- Cancer in Males: Implications for Sperm Quality, Fertility, and Progeny Outcome.- Sperm Chromatin and Environmental Factors.- Effects of Male Accessory Gland Infection on Sperm Parameters.- Antioxidants and Sperm DNA Damage.- Part III: Sperm Chromatin and Assisted Reproductive Technologies (ART).- The Impact of Sperm Processing and Cryopreservation on Sperm DNA Integrity.- Sperm Chromatin and ART (IUI, IVF and ICSI).- Sperm DNA Damage and Pregnancy Loss after IVF and ICSI.- Postnatal Effects of Sperm Chromatin Damage.- Evaluation of Chromatin and DNA Integrity in Testicular Sperm.- Clinical Utility of Sperm DNA Integrity Tests.