Arnauld E. Nicogossian, MD, FACPM, FACP Distinguished Research Professor Schar School of Policy and Government, George Mason University Senior Editor, World Medical and Health Policy Journal, and Former NASA Associate Administrator, Office of Life and Microgravity Sciences and Applications Arlington, VA, USA Richard S. Williams, MD, FACS Chief Health and Medical Officer National Aeronautics and Space Administration Washington, DC, USA Carolyn L. Huntoon, PhD Former Director NASA Lyndon B. Johnson Space Center & Assistant Secretary of Environmental Management, DOE Barrington, Rhode Island, USA Charles R. Doarn, MBA Special Assistant to the Chief Health and Medical Officer NASA Office of the Chief Health and Medical Officer Washington, DC, USA Research Professor Department of Family and Community Medicine School of Medicine Unviersity of Cincinnati Cincinnati, Ohio, USA  James D. Polk, DO, MS, MMM, CPE, FACOEP Senior Medical Officer  National Aeronautics and Space Administration Former Chief Flight Medicine NASA Lyndon B. Johnson Space Center Houston, Texas, USA Victor S. Schneider, MD Program Executive Human Exploration & Operations Mission Directorate NASA HQ Visiting Associate Professor University of Texas Medical Branch, Galveston, Texas, USA

• Dedication.- Foreword.- Preface.- Acknowledgments.- Contributors.- Introduction.- Section I: Introduction to Space Medicine.- Chapter 1:Evolution of Human Capabilities and Space Medicine.- Chapter 2: The Environment of Space Exploration.- Chapter 3:Living and Working in Space: An Overview of Physiological Adaptation, Performance, and Health Risks.- Section II: Space Craft Environments.- Chapter 4: Toxicology.- Chapter 5: Microbiology.- Chapter 6: Acoustics and Audition.- Chapter 7: Radiation Health and Protection.- Section III: Space Flight and Crew Health: Adaptation, Pathophysiology, Rehabilitation, and Countermeasures.- Chapter 8: Cardiopulmonary System: Aeromedical Considerations.- Chapter 9: Neurology.- Chapter 10: Regulatory Physiology.- Chapter 11:Metabolism and Nutrition.- Chapter 12: Clinical Pharmacology and Therapeutics.- Chapter 13:Musculoskeletal Adaptation to Space Flight.- Chapter 14: Behavioral Health and Performance.- Section IV: Occupational Health and Safety Issues in Space Flight.- Chapter 15:Principles of Crew Health Monitoring and Care.- Chapter 16: International Dimension of Space Medicine.- Section V: Ground-Based and Academic Training Programs.- Chapter 17: Simulations and Analogs (Test-Beds).- Chapter 18: Training in Space Medicine.- Section VI:Future Perspectives.- Chapter 19: Commercial Space Tourism and Space as a Biomedical Laboratory.- Acronyms.

This book was awarded by The International Academy of Astronautics (IAA) in 2018 with the Life Science Book Award.“There is no question but this is a stunning textbook of use in a variety of settings. Certainly flight surgeons, biomedical researchers, and other scientists will view it a major boon to their efforts.” (Roger D. Launius, SPACE TIMES, Vol.56 (6), November – December, 2017)“This fourth edition … provides succinct historical accounts of their evolution, and offers assessments of the increasingly more sophisticated information available on the space environment, risks to astronaut health, and countermeasures available to protect the human body. … Certainly, flight surgeons, biomedical researchers, and other scientists will view it a major boon to their efforts. … Space Physiology and Medicine has many sections that will greatly enhance knowledge of this most important of all aspects of human space exploration.” (Roger D. Launius, Quest Magazine, Vol. 24 (4), 2017)