Somatostatin

Häftad, Engelska, 1992

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One of the phylogenetically oldest hormones, somatostatin is a regulatory peptide with remarkable characteristics. It is a nonclassical neurotransmitter discovered less than 20 years ago both in the central nervous system and in the gastroenteropancreatic system. It regulates the secretion of both pituitary and digestive hormones, it ensures nutrient homeostasis and it has therapeutic uses. This volume deals withall these aspects.

Produktinformation

Utgivningsdatum1992-07-17
Mått210 x 277 x 5 mm
Vikt218 g
FormatHäftad
SpråkEngelska
SerieBasic and Clinical Aspects of Neuroscience
Antal sidor66
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540545699

Tillhör följande kategorier

Farmakologi inom Medicin
Neurologi och klinisk neurofysiologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

General Aspects of the Biology and Function of Somatostatin.- Molecular Heterogeneity of Somatostatin.- Evolution of Somatostatin Genes and Gene Products.- Anatomical Distribution of Somatostatin Cells.- Somatostatin in the Blood and Other Body Fluids.- Actions of Somatostatin.- Molecular Model of Somatostatin Action.- Regulation of Somatostatin Secretion and Gene Expression.- Physiological Significance of Somatostatin.- Somatostatin in Disease.- References.- Somatostatin Receptors in the Central Nervous System.- Somatostatin Receptors.- Somatostatin Receptors in Pathology.- Conclusion.- References.- Somatostatin in Neuropsychiatric Disorders.- Neuropsychiatric Disease-Related Alterations.- Central Nervous System Effects of Somatostatin.- Somatostatin in Affective Disorder: Clinical Relevance.- Endocrine Correlates.- Role in Seizure Disorders and Effects of Psychopharmacological Agents..- Conclusions.- References.- The Physiological Role of Somatostatin in the Regulation of Nutrient Homeostasis.- Release of Somatostatin.- Mechanisms of Somatostatin Release.- Physiological Effects of Somatostatin.- Somatostatin and Nutrient Entry into the Circulation.- References.- Therapeutic Use of Somatostatin and Octreotide Acetate in Neuroendocrine Tumors.- Pharmacology of Octreotide Acetate.- The Effects of Somatostatin and Octreotide on the Pituitary.- The Effects of Somatostatin and Octreotide on Neuroendocrine Tumors of the Gut.- Unresolved Issues.- References.