Sodium Channels and Neuronal Hyperexcitability

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

• Chair's Introduction: Sodium Channels and Neuronal Dysfunction -Emerging Concepts, Converging Themes (Stephen G. Waxman). Studies of Multimodal Gating of the Sodium Channel (Richard D. Keynes). Molecular Basis for Function in Sodium Channels (Richard Horn). Diverse Functions and Dynamic Expression of Neuronal Sodium Channels (Stephen G. Waxman, et al.). Enhanced Transmission of Glutamate Current Flowing from the Dendrite to the Soma in Rat Neocortical Layer 5 Neurons (Wayne E. Crill, et al.). Mutations of Voltage-gated Sodium Channels in Movement Disorders End Epilepsy (Miriam H. Meisler, et al.). Channelopathies: Episodic Disorders of the Nervous System (Louis Ptacek). Sodium Channels Gene Expression and Epilepsy (Jeffrey L. Noebels). Subunits: Players in Neuronal Hyperexcitability? (Lori L. Isom). Modulation of Sodium Channels in Primary Afferent Neurons (Stuart Bevan, et al.). Sodium Channels in Primary Sensory Neurons: Relationship to Pain States (John N. Wood, et al.). Sodium Channels an Epilepy Electrophysiology (Michael M. Segal). Therapuetic Concentrations of Local Anaesthetics Unveil the Potential Role of Sodium Channels in Neuropathic Pain (Gary R. Strichartz, et al.). Molecular Mechanisms of Gating and Drug Block of Sodium Channels (William A. Catterall). Final General Discussion. Index of Contributors. Subject Index.